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Impact of FTO genotypes on BMI and weight in polycystic ovary syndrome : a systematic review and meta-analysis

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Impact of FTO genotypes on BMI and weight in polycystic ovary syndrome : a systematic review and meta-analysis

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dc.contributor.author Wojciechowski, Piotr [SAP20001322] pl
dc.contributor.author Lipowska, A. pl
dc.contributor.author Ryś, P. pl
dc.contributor.author Ewens, K. G. pl
dc.contributor.author Franks, S. pl
dc.contributor.author Tan, S. pl
dc.contributor.author Lerchbaum, E. pl
dc.contributor.author Vcelak, J. pl
dc.contributor.author Attaoua, R. pl
dc.contributor.author Straczkowski, M. pl
dc.contributor.author Azziz, R. pl
dc.contributor.author Barber, T. M. pl
dc.contributor.author Hinney, A. pl
dc.contributor.author Obermayer-Pietsch, B. pl
dc.contributor.author Lukasova, P. pl
dc.contributor.author Bendlova, B. pl
dc.contributor.author Grigorescu, F. pl
dc.contributor.author Kowalska, I. pl
dc.contributor.author Goodarzi, M. O. pl
dc.contributor.author Strauss III, J. F. pl
dc.contributor.author McCarthy, M. I. pl
dc.contributor.author Małecki, Maciej [SAP20001383] pl
dc.date.accessioned 2020-08-28T06:57:34Z
dc.date.available 2020-08-28T06:57:34Z
dc.date.issued 2012 pl
dc.identifier.issn 0012-186X pl
dc.identifier.uri https://ruj.uj.edu.pl/xmlui/handle/item/244863
dc.language eng pl
dc.rights Udzielam licencji. Uznanie autorstwa - Użycie niekomercyjne 2.0 *
dc.rights.uri http://creativecommons.org/licenses/by-nc/2.0/legalcode *
dc.title Impact of FTO genotypes on BMI and weight in polycystic ovary syndrome : a systematic review and meta-analysis pl
dc.type JournalArticle pl
dc.description.physical 2636-2645 pl
dc.abstract.en Aims/hypothesis FTO gene single nucleotide polymorphisms (SNPs) have been shown to be associated with obesity-related traits and type 2 diabetes. Several small studies have suggested a greater than expected effect of the FTO rs9939609 SNP on weight in polycystic ovary syndrome (PCOS). We therefore aimed to examine the impact of FTO genotype on BMI and weight in PCOS. Methods A systematic search of medical databases (PubMed, EMBASE and Cochrane CENTRAL) was conducted up to the end of April 2011. Seven studies describing eight distinct PCOS cohorts were retrieved; seven were genotyped for SNP rs9939609 and one for SNP rs1421085. The per allele effect on BMI and body weight increase was calculated and subjected to meta-analysis. Results A total of 2,548 women with PCOS were included in the study; 762 were TT homozygotes, 1,253 had an AT/CT genotype, and 533 were AA/CC homozygotes. Each additional copy of the effect allele (A/C) increased the BMI by a mean of 0.19 z score units (95% CI 0.13, 0.24; p = 2.26 × 10−11) and body weight by a mean of 0.20 z score units (95% CI 0.14, 0.26; p = 1.02 × 10−10). This translated into an approximately 3.3 kg/m2 increase in BMI and an approximately 9.6 kg gain in body weight between TT and AA/CC homozygotes. The association between FTO genotypes and BMI was stronger in the cohorts with PCOS than in the general female populations from large genome-wide association studies. Deviation from an additive genetic model was observed in heavier populations. Conclusions/interpretation The effect of FTO SNPs on obesity-related traits in PCOS seems to be more than two times greater than the effect found in large population-based studies. This suggests an interaction between FTO and the metabolic context or polygenic background of PCOS. pl
dc.subject.en BMI pl
dc.subject.en FTO pl
dc.subject.en meta-analysis pl
dc.subject.en polycystic ovary syndrome pl
dc.subject.en systematic review pl
dc.subject.en weight pl
dc.description.volume 55 pl
dc.identifier.doi 10.1007/s00125-012-2638-6 pl
dc.identifier.eissn 1432-0428 pl
dc.title.journal Diabetologia pl
dc.language.container eng pl
dc.affiliation Wydział Lekarski : Klinika Chorób Metabolicznych pl
dc.affiliation Wydział Lekarski : Instytut Pediatrii pl
dc.subtype Article pl
dc.rights.original CC-BY-NC; otwarte czasopismo; ostateczna wersja wydawcy; w momencie opublikowania; 0 pl
dc.identifier.project ROD UJ / OP pl
.pointsMNiSW [2012 A]: 40


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Udzielam licencji. Uznanie autorstwa - Użycie niekomercyjne 2.0 Except where otherwise noted, this item's license is described as Udzielam licencji. Uznanie autorstwa - Użycie niekomercyjne 2.0