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Temporal sequence of the human RBCs' vesiculation observed in nano-scale with application of AFM and complementary techniques
red blood cells (RBCs)
RBC-derived microparticles (RMPs)
atomic force microscopy (AFM)
packed red blood cells (PRBCs)
membrane alterations
Based on the multimodal characterization of human red blood cells (RBCs), the link between the storage-related sequence of the nanoscale changes in RBC membranes in the relation to their biochemical profile as well as mechanical and functional properties was presented. On the background of the accumulation of RBCs waste products, programmed cell death and impaired rheological properties, progressive alterations in the RBC membranes including changes in their height and diameter as well as the in situ characterization of RBC-derived microparticles (RMPs) on the RBCs surface were presented. The advantage of atomic force microscopy (AFM) in RMPs visualization, even at the very early stage of vesiculation, was shown based on the results revealed by other reference techniques. The nanoscale characterization of RMPs was correlated with a decrease in cholesterol and triglycerides levels in the RBC membranes, proving the link between the lipids leakage from RBCs and the process of vesiculation.
cris.lastimport.wos | 2024-04-09T19:08:25Z | |
dc.abstract.en | Based on the multimodal characterization of human red blood cells (RBCs), the link between the storage-related sequence of the nanoscale changes in RBC membranes in the relation to their biochemical profile as well as mechanical and functional properties was presented. On the background of the accumulation of RBCs waste products, programmed cell death and impaired rheological properties, progressive alterations in the RBC membranes including changes in their height and diameter as well as the in situ characterization of RBC-derived microparticles (RMPs) on the RBCs surface were presented. The advantage of atomic force microscopy (AFM) in RMPs visualization, even at the very early stage of vesiculation, was shown based on the results revealed by other reference techniques. The nanoscale characterization of RMPs was correlated with a decrease in cholesterol and triglycerides levels in the RBC membranes, proving the link between the lipids leakage from RBCs and the process of vesiculation. | pl |
dc.affiliation | Wydział Lekarski : Klinika Hematologii | pl |
dc.affiliation | Wydział Chemii : Zakład Fizyki Chemicznej | pl |
dc.affiliation | Pion Prorektora ds. badań naukowych : Jagiellońskie Centrum Rozwoju Leków | pl |
dc.cm.id | 100433 | |
dc.contributor.author | Kaczmarska, Magdalena - 120218 | pl |
dc.contributor.author | Grosicki, Marek - 219940 | pl |
dc.contributor.author | Bułat, Katarzyna - 255683 | pl |
dc.contributor.author | Mardyla, Mateusz | pl |
dc.contributor.author | Szczęsny-Małysiak, Ewa - 104206 | pl |
dc.contributor.author | Blat, Aneta - 204599 | pl |
dc.contributor.author | Dybaś, Jakub - 178981 | pl |
dc.contributor.author | Sacha, Tomasz - 133344 | pl |
dc.contributor.author | Marzec, Katarzyna M. - 145326 | pl |
dc.date.accessioned | 2020-07-30T11:59:52Z | |
dc.date.available | 2020-07-30T11:59:52Z | |
dc.date.issued | 2020 | pl |
dc.date.openaccess | 0 | |
dc.description.accesstime | w momencie opublikowania | |
dc.description.version | ostateczna wersja wydawcy | |
dc.description.volume | 28 | pl |
dc.identifier.articleid | 102221 | pl |
dc.identifier.doi | 10.1016/j.nano.2020.102221 | pl |
dc.identifier.eissn | 1549-9642 | pl |
dc.identifier.issn | 1549-9634 | pl |
dc.identifier.project | ROD UJ / OP | pl |
dc.identifier.uri | https://ruj.uj.edu.pl/xmlui/handle/item/243194 | |
dc.language | eng | pl |
dc.language.container | eng | pl |
dc.rights | Udzielam licencji. Uznanie autorstwa - Użycie niekomercyjne - Bez utworów zależnych 4.0 Międzynarodowa | * |
dc.rights.licence | CC-BY-NC-ND | |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/4.0/legalcode.pl | * |
dc.share.type | inne | |
dc.subject.en | red blood cells (RBCs) | pl |
dc.subject.en | RBC-derived microparticles (RMPs) | pl |
dc.subject.en | atomic force microscopy (AFM) | pl |
dc.subject.en | packed red blood cells (PRBCs) | pl |
dc.subject.en | membrane alterations | pl |
dc.subtype | Article | pl |
dc.title | Temporal sequence of the human RBCs' vesiculation observed in nano-scale with application of AFM and complementary techniques | pl |
dc.title.journal | Nanomedicine. Nanotechnology, Biology and Medicine | pl |
dc.type | JournalArticle | pl |
dspace.entity.type | Publication |
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