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Temporal sequence of the human RBCs' vesiculation observed in nano-scale with application of AFM and complementary techniques
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Temporal sequence of the human RBCs' vesiculation observed in nano-scale with application of AFM and complementary techniques
Bibliographic description
| title: | Temporal sequence of the human RBCs' vesiculation observed in nano-scale with application of AFM and complementary techniques |
| author: | Kaczmarska Magdalena  , Grosicki Marek , Bułat Katarzyna , Mardyla Mateusz, Szczęsny-Małysiak Ewa , Blat Aneta , Dybaś Jakub , Sacha Tomasz , Marzec Katarzyna M.
|
| journal title: | Nanomedicine. Nanotechnology, Biology and Medicine |
| volume: | 28 |
| date of publication : | 2020 |
| article ID: | 102221 |
| ISSN: |
1549-9634 |
| eISSN: |
1549-9642 |
| DOI: | |
| language: | English |
| journal language: | English |
| abstract in English: | Based on the multimodal characterization of human red blood cells (RBCs), the link between the storage-related sequence of the nanoscale changes in RBC membranes in the relation to their biochemical profile as well as mechanical and functional properties was presented. On the background of the accumulation of RBCs waste products, programmed cell death and impaired rheological properties, progressive alterations in the RBC membranes including changes in their height and diameter as well as the in situ characterization of RBC-derived microparticles (RMPs) on the RBCs surface were presented. The advantage of atomic force microscopy (AFM) in RMPs visualization, even at the very early stage of vesiculation, was shown based on the results revealed by other reference techniques. The nanoscale characterization of RMPs was correlated with a decrease in cholesterol and triglycerides levels in the RBC membranes, proving the link between the lipids leakage from RBCs and the process of vesiculation. |
| keywords in English: | red blood cells (RBCs), RBC-derived microparticles (RMPs), atomic force microscopy (AFM), packed red blood cells (PRBCs), membrane alterations |
| affiliation: | Wydział Lekarski : Klinika Hematologii, Wydział Chemii : Zakład Fizyki Chemicznej, Pion Prorektora ds. badań naukowych i funduszy strukturalnych : Jagiellońskie Centrum Rozwoju Leków |
| type: | journal article |
| subtype: | academic paper |
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Except where otherwise noted, this item's license is described as Udzielam licencji. Uznanie autorstwa - Użycie niekomercyjne - Bez utworów zależnych 4.0 Międzynarodowa
Projekt „Repozytorium otwartego dostępu do dorobku naukowego i dydaktycznego UJ” współfinansowany w ramach poddziałania 2.3.1 „Cyfrowe udostępnianie zasobów nauki” Programu Operacyjnego Polska Cyfrowa z Europejskiego Funduszu Rozwoju Regionalnego i budżetu państwa na podstawie umowy o dofinansowanie nr POPC.02.03.01-00-0030/17-00
