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Simplex optimization of headspace factors for headspace gas chromatography determination of residual solvents in pharmaceutical products

Simplex optimization of headspace factors for headspace ...

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dc.contributor.author Grodowska, Katarzyna [USOS57660] pl
dc.contributor.author Parczewski, Andrzej [SAP11005091] pl
dc.date.accessioned 2014-12-23T16:24:30Z
dc.date.available 2014-12-23T16:24:30Z
dc.date.issued 2013 pl
dc.identifier.issn 0001-6837 pl
dc.identifier.uri http://ruj.uj.edu.pl/xmlui/handle/item/2402
dc.language eng pl
dc.title Simplex optimization of headspace factors for headspace gas chromatography determination of residual solvents in pharmaceutical products pl
dc.type JournalArticle pl
dc.description.physical 181-189 pl
dc.identifier.weblink http://www.ptfarm.pl/pub/File/Acta_Poloniae/2013/2/181.pdf pl
dc.abstract.en The purpose of the present work was to find optimum conditions of headspace gas chromatography (HS-GC) determination of residual solvents which usually appear in pharmaceutical products. Two groups of solvents were taken into account in the present examination. Group I consisted of isopropanol, n-propanol, isobutanol, n-butanol and 1,4-dioxane and group II included cyclohexane, n-hexane and n-heptane. The members of the groups were selected in previous investigations in which experimental design and chemometric methods were applied. Four factors were taken into consideration in optimization which describe HS conditions: sample volume, equilibration time, equilibrium temperature and NaCl concentration in a sample. The relative GC peak area served as an optimization criterion which was considered separately for each analyte. Sequential variable size simplex optimization strategy was used and the progress of optimization was traced and visualized in various ways simultaneously. The optimum HS conditions appeared different for the groups of solvents tested, which proves that influence of experimental conditions (factors) depends on analyte properties. The optimization resulted in significant signal increase (from seven to fifteen times). pl
dc.subject.en residual solvents pl
dc.subject.en headspace-gas chromatography pl
dc.subject.en optimization pl
dc.subject.en simplex method pl
dc.description.volume 70 pl
dc.description.number 2 pl
dc.identifier.eissn 2353-5288 pl
dc.title.journal Acta Poloniae Pharmaceutica. Drug Research pl
dc.language.container eng pl
dc.date.accession 2016-05-27 pl
dc.affiliation Wydział Chemii : Zakład Chemii Analitycznej pl
dc.subtype Article pl
dc.rights.original OTHER; otwarte czasopismo; ostateczna wersja wydawcy; w momencie opublikowania; 0; pl
.pointsMNiSW [2013 A]: 15


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