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AM3 inhibits LPS-induced iNOS expression in mice

AM3 inhibits LPS-induced iNOS expression in mice

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dc.contributor.author Majano, Pedro pl
dc.contributor.author Alonso-Lebrero, José Luis pl
dc.contributor.author Kyzioł, Agnieszka [SAP11019297] pl
dc.contributor.author Martín-Vichez, Samuel pl
dc.contributor.author Molina-Jiménez, Francisca pl
dc.contributor.author Brieva, Aurora pl
dc.contributor.author Pivel, Juan Pablo pl
dc.contributor.author González, Salvador pl
dc.contributor.author López-Cabrera, Manuel pl
dc.contributor.author Moreno-Otero, Ricardo pl
dc.date.accessioned 2014-12-20T10:59:05Z
dc.date.available 2014-12-20T10:59:05Z
dc.date.issued 2005 pl
dc.identifier.issn 1567-5769 pl
dc.identifier.uri http://ruj.uj.edu.pl/xmlui/handle/item/2389
dc.language eng pl
dc.title AM3 inhibits LPS-induced iNOS expression in mice pl
dc.type JournalArticle pl
dc.description.physical 1165-1170 pl
dc.description.additional Na publikacji autorka Kyzioł Agnieszka podpisana jako Jańczyk Agnieszka. pl
dc.abstract.en We have analyzed the effect of a patented glycoconjugate of natural origin, AM3 (commercially available under the name Inmunoferon) in the expression of iNOS induced by administration of LPS in mice. We have observed that oral treatment with the drug daily for 6 days reduced the levels of expression of iNOS induced by an intravenous pulse of LPS. This effect was significant in the lungs and kidneys, but it was much more marked in the liver. In addition, the levels of nitric oxide in serum were clearly decreased upon treatment with AM3. Together, these results suggest that AM3 modulates the nitric oxide response and points to a possible role for AM3 in the control of the inflammatory response. pl
dc.subject.en nitric oxide pl
dc.subject.en inmunoferon pl
dc.subject.en AM3 pl
dc.subject.en anti-inflammatory response pl
dc.subject.en iNOS pl
dc.description.volume 5 pl
dc.description.number 7-8 pl
dc.identifier.doi 10.1016/j.intimp.2005.02.009 pl
dc.identifier.eissn 1878-1705 pl
dc.title.journal International Immunopharmacology pl
dc.language.container eng pl
dc.affiliation Wydział Chemii : Zakład Chemii Nieorganicznej pl
dc.subtype Article pl


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