Repozytorium Uniwersytetu Jagiellońskiego

Pulmonary metastases of the A549-derived lung adenocarcinoma tumors growing in nude mice : a multiple case study

Pokaż opis pozycji

dc.contributor.author

Jakubowska, Monika [SAP14001668]

pl
dc.contributor.author

Śniegocka, Martyna

pl
dc.contributor.author

Podgórska, Ewa

pl
dc.contributor.author

Michalczyk-Wetula, Dominika [SAP13902344]

pl
dc.contributor.author

Urbańska, Krystyna [SAP11009894]

pl
dc.contributor.author

Susz, Anna

pl
dc.contributor.author

Fiedor, Leszek [SAP11012795]

pl
dc.contributor.author

Pyka, Janusz [SAP11117259]

pl
dc.contributor.author

Płonka, Przemysław [SAP11015581]

pl
dc.date.accessioned

2014-12-20T10:46:11Z

dc.date.available

2014-12-20T10:46:11Z

dc.date.issued

2013

pl
dc.identifier.issn

0001-527X

pl
dc.identifier.uri

http://ruj.uj.edu.pl/xmlui/handle/item/2380

dc.language

eng

pl
dc.title

Pulmonary metastases of the A549-derived lung adenocarcinoma tumors growing in nude mice : a multiple case study

pl
dc.type

JournalArticle

pl
dc.description.physical

323-330

pl
dc.identifier.weblink

http://www.actabp.pl/pdf/3_2013/323.pdf

pl
dc.abstract.en

Lung adenocarcinoma is a leading human malignancy with fatal prognosis. Ninety percent of the deaths, however, are caused by metastases. The model of subcutaneous tumor xenograft in nude mice was adopted to study the growth of control and photodynamically treated tumors derived from the human A549 lung adenocarcinoma cell line. As a side-result of the primary studies, observations on the metastasis of these tumors to the murine lungs were collected, and reported in the present paper. The metastasizing primary tumors were drained by a prominent number of lymphatic vessels. The metastatic tissue revealed the morphology of well-differentiated or trans-differentiated adenocarcinoma. Further histological and histochemical analyses demonstrated the presence of golden-brown granules in the metastatic tissue, similar to these found in the tumor tissue. In contrast to the primary tumors, the electron paramagnetic resonance spectroscopy revealed no nitric oxide - hemoglobin complexes (a source of intense paramagnetic signals), in the metastases. No metastases were found in other murine organs; however, white infarctions were identified in a single liver. Taken together, the A549-derived tumors growing subcutaneously in nude mice can metastasize and grow on site in the pulmonary tissue. Thus, they can represent an alternative for the model of induced metastatic nodule formation, following intravenous administration of the cancerous cells.

pl
dc.subject.en

adenocarcinoma

pl
dc.subject.en

histological analysis

pl
dc.subject.en

metastases

pl
dc.subject.en

nude mice

pl
dc.subject.en

photodynamic therapy

pl
dc.subject.en

zinc pheophorbide a

pl
dc.description.volume

60

pl
dc.description.number

3

pl
dc.identifier.eissn

1734-154X

pl
dc.title.journal

Acta Biochimica Polonica

pl
dc.language.container

eng

pl
dc.date.accession

2015-04-20

pl
dc.affiliation

Wydział Biochemii, Biofizyki i Biotechnologii : Zakład Biofizyki

pl
dc.affiliation

Wydział Biochemii, Biofizyki i Biotechnologii : Zakład Biofizyki Molekularnej

pl
dc.affiliation

Wydział Biochemii, Biofizyki i Biotechnologii : Zakład Fizjologii i Biochemii Roślin

pl
dc.subtype

Article

pl
dc.rights.original

OTHER; otwarte czasopismo; ostateczna wersja wydawcy; w momencie opublikowania; 0

pl
.pointsMNiSW

[2013 A]: 15



Pliki tej pozycji

Plik Rozmiar Format Przeglądanie

Nie ma plików powiązanych z tą pozycją.

Pozycja umieszczona jest w następujących kolekcjach

Pokaż opis pozycji

Szukaj w RUJ


Szukanie zaawansowane

Statystyki