Repozytorium Uniwersytetu Jagiellońskiego

Pulmonary metastases of the A549-derived lung adenocarcinoma tumors growing in nude mice : a multiple case study

Pulmonary metastases of the A549-derived lung ...

Metadane (Dublin Core)

dc.contributor.author Jakubowska, Monika [SAP14001668] pl
dc.contributor.author Śniegocka, Martyna [SAP14016254] pl
dc.contributor.author Podgórska, Ewa [USOS96682] pl
dc.contributor.author Michalczyk-Wetula, Dominika [SAP13902344] pl
dc.contributor.author Urbańska, Krystyna [SAP11009894] pl
dc.contributor.author Susz, Anna pl
dc.contributor.author Fiedor, Leszek [SAP11012795] pl
dc.contributor.author Pyka, Janusz [SAP11117259] pl
dc.contributor.author Płonka, Przemysław [SAP11015581] pl
dc.date.accessioned 2014-12-20T10:46:11Z
dc.date.available 2014-12-20T10:46:11Z
dc.date.issued 2013 pl
dc.identifier.issn 0001-527X pl
dc.identifier.uri http://ruj.uj.edu.pl/xmlui/handle/item/2380
dc.language eng pl
dc.title Pulmonary metastases of the A549-derived lung adenocarcinoma tumors growing in nude mice : a multiple case study pl
dc.type JournalArticle pl
dc.description.physical 323-330 pl
dc.identifier.weblink http://www.actabp.pl/pdf/3_2013/323.pdf pl
dc.abstract.en Lung adenocarcinoma is a leading human malignancy with fatal prognosis. Ninety percent of the deaths, however, are caused by metastases. The model of subcutaneous tumor xenograft in nude mice was adopted to study the growth of control and photodynamically treated tumors derived from the human A549 lung adenocarcinoma cell line. As a side-result of the primary studies, observations on the metastasis of these tumors to the murine lungs were collected, and reported in the present paper. The metastasizing primary tumors were drained by a prominent number of lymphatic vessels. The metastatic tissue revealed the morphology of well-differentiated or trans-differentiated adenocarcinoma. Further histological and histochemical analyses demonstrated the presence of golden-brown granules in the metastatic tissue, similar to these found in the tumor tissue. In contrast to the primary tumors, the electron paramagnetic resonance spectroscopy revealed no nitric oxide - hemoglobin complexes (a source of intense paramagnetic signals), in the metastases. No metastases were found in other murine organs; however, white infarctions were identified in a single liver. Taken together, the A549-derived tumors growing subcutaneously in nude mice can metastasize and grow on site in the pulmonary tissue. Thus, they can represent an alternative for the model of induced metastatic nodule formation, following intravenous administration of the cancerous cells. pl
dc.subject.en adenocarcinoma pl
dc.subject.en histological analysis pl
dc.subject.en metastases pl
dc.subject.en nude mice pl
dc.subject.en photodynamic therapy pl
dc.subject.en zinc pheophorbide a pl
dc.description.volume 60 pl
dc.description.number 3 pl
dc.identifier.eissn 1734-154X pl
dc.title.journal Acta Biochimica Polonica pl
dc.language.container eng pl
dc.date.accession 2015-04-20 pl
dc.affiliation Wydział Biochemii, Biofizyki i Biotechnologii : Zakład Biofizyki pl
dc.affiliation Wydział Biochemii, Biofizyki i Biotechnologii : Zakład Biofizyki Molekularnej pl
dc.affiliation Wydział Biochemii, Biofizyki i Biotechnologii : Zakład Fizjologii i Biochemii Roślin pl
dc.subtype Article pl
dc.rights.original OTHER; otwarte czasopismo; ostateczna wersja wydawcy; w momencie opublikowania; 0 pl
.pointsMNiSW [2013 A]: 15


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