Kinetics and mechanism of the substitution behaviour of Pd(II) piperazine complexes with different biologically relevant nucleophiles

Bibliographic description

title:	Kinetics and mechanism of the substitution behaviour of Pd(II) piperazine complexes with different biologically relevant nucleophiles
author:	van Eldik Rudi , Brindell Małgorzata , Shoukry Azza
journal title:	Dalton Transactions
volume:	2007
issue:	37
date of publication :	2007
pages:	4169-4174
ISSN:	1477-9226
eISSN:	1477-9234
DOI:	10.1039/b706856e
language:	English
journal language:	English
abstract in English:	The interaction of the palladium(II) complex $[Pd(Pip)(H_{2}O)_{2}]^{2+}$, where Pip is piperazine, with a series of biologically relevant nucleophiles including guanosine-5'-monophosphate, L-methionine and thiourea was studied under pseudo-first-order conditions as a function of nucleophile concentration and temperature, using UV-Vis spectrophotometric and stopped-flow techniques. The reactions were found to occur in two subsequent steps. For the sulfur donor containing nucleophiles thiourea and L-methionine, a third reaction step, the displacement of the labilized amine, as a result of the strong trans-effect of S-donor ligands, was observed. The activation parameters for all reactions studied suggest an associative substitution mechanism.
affiliation:	Wydział Chemii : Zakład Chemii Nieorganicznej
type:	journal article
subtype:	academic paper

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