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Verteporfin, photofrin II, and merocyanine 540 as PDT photosensitizers against melanoma cells

Verteporfin, photofrin II, and merocyanine 540 as ...

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dc.contributor.author Nowak-Sliwinska, Patrycja pl
dc.contributor.author Karocki, Andrzej pl
dc.contributor.author Elas, Martyna [SAP11015756] pl
dc.contributor.author Pawlak, Anna [SAP11016784] pl
dc.contributor.author Stochel, Grażyna [SAP11011061] pl
dc.contributor.author Urbańska, Katarzyna pl
dc.date.accessioned 2014-12-18T08:16:07Z
dc.date.available 2014-12-18T08:16:07Z
dc.date.issued 2006 pl
dc.identifier.issn 0006-291X pl
dc.identifier.uri http://ruj.uj.edu.pl/xmlui/handle/item/2320
dc.language eng pl
dc.title Verteporfin, photofrin II, and merocyanine 540 as PDT photosensitizers against melanoma cells pl
dc.type JournalArticle pl
dc.description.physical 549-555 pl
dc.abstract.en The efficiency of photodynamic effect (PDE) for Photofrin II (PfII), Verteporfin, and Merocyanine 540 (MC540) was compared against neoplastic cells. Triplet state lifetimes and singlet molecular oxygen quantum yields were correlated with biological effect. PfII triplet lifetime was two times longer than that of Verteporfin, however, its singlet molecular oxygen quantum yield was two times lower in comparison with Verteporfin. High singlet molecular oxygen quantum yield of Verteporfin resulted in high biological efficacy. To achieve 50% mortality of cells four times lower light dose and five times lower concentration of Verteporfin were applied in comparison with PfII. The same level of cell damage was reached using 10 times higher light dose and two times higher concentration of MC540 in comparison with PfII. Our results confirm that singlet molecular oxygen based mechanism, prevalent for Verteporfin and PfII, was highly effective against melanoma cells. Verteporfin can be used at small doses with high cellular damage efficiency. pl
dc.subject.en photodynamic effect pl
dc.subject.en photofrin II pl
dc.subject.en merocyanine 540 pl
dc.subject.en verteporfin pl
dc.subject.en singlet molecular oxygen pl
dc.subject.en triplet lifetime pl
dc.description.volume 349 pl
dc.description.number 2 pl
dc.identifier.doi 10.1016/j.bbrc.2006.08.060 pl
dc.identifier.eissn 1090-2104 pl
dc.title.journal Biochemical and Biophysical Research Communications pl
dc.language.container eng pl
dc.affiliation Wydział Chemii : Zakład Chemii Nieorganicznej pl
dc.affiliation Wydział Biochemii, Biofizyki i Biotechnologii : Zakład Biofizyki pl
dc.subtype Article pl


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