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A comprehensive approach to study liver tissue : spectroscopic imaging and histochemical staining

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A comprehensive approach to study liver tissue : spectroscopic imaging and histochemical staining

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dc.contributor.author Kochan, Kamila [USOS80030] pl
dc.contributor.author Maślak, Edyta [SAP14006481] pl
dc.contributor.author Kostogrys, Renata [SAP20011854] pl
dc.contributor.author Chłopicki, Stefan [SAP20000969] pl
dc.contributor.author Barańska, Małgorzata [SAP11016906] pl
dc.date.accessioned 2015-11-19T12:59:16Z
dc.date.available 2015-11-19T12:59:16Z
dc.date.issued 2013 pl
dc.identifier.issn 2212-8794 pl
dc.identifier.uri http://ruj.uj.edu.pl/xmlui/handle/item/16933
dc.language eng pl
dc.title A comprehensive approach to study liver tissue : spectroscopic imaging and histochemical staining pl
dc.type JournalArticle pl
dc.description.physical 331-337 pl
dc.abstract.en The liver, due to its central role in the regulation of metabolism and multiplicity of its other functions, is exposed to a high number of pathogenic factors. Non-Alcoholic Fatty Liver Disease (NAFLD), manifested mainly by changes in liver's lipid profile, represent one of the most frequently occurring liver pathology, that is often underestimated at an early stage of its development. The pathogenesis as well as the treatment of NAFLD has not been fully established yet. The difficulty associated with this arises from the need to detect very subtle changes. With regard to fulfilling these expectations, from all available research methods vibrational spectroscopic imaging techniques attract special attention, as they possess a great potential to detect even minor variation in chemical composition of the sample. The specificity of infrared imaging and Raman mapping along with their complementarity provides the ability to obtain comprehensive information on the molecular level. Here we present an approach for the study of liver tissue based on the simultaneous application of vibrational spectroscopic imaging and multirivate data analysis combined with histochemical staining. pl
dc.subject.en liver pl
dc.subject.en Raman mapping pl
dc.subject.en lipids pl
dc.subject.en FT-IR pl
dc.subject.en cluster analysis pl
dc.subject.en imaging pl
dc.subject.en staining pl
dc.subject.en ORO pl
dc.description.volume 2 pl
dc.description.number 4 pl
dc.description.publication 0,8 pl
dc.identifier.doi 10.3233/BSI-130050 pl
dc.identifier.eissn 2212-8808 pl
dc.title.journal Biomedical Spectroscopy and Imaging pl
dc.language.container eng pl
dc.affiliation Wydział Chemii : Zakład Fizyki Chemicznej pl
dc.affiliation Pion Rektora : Jagiellońskie Centrum Rozwoju Leków pl
dc.affiliation Wydział Lekarski : Zakład Farmakologii pl
dc.subtype Article pl
dc.rights.original bez licencji pl


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