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Analysis of local gyrification index using a novel shape-adaptive kernel and the standard FreeSurfer spherical kernel : evidence from chronic schizophrenia outpatients

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Analysis of local gyrification index using a novel shape-adaptive kernel and the standard FreeSurfer spherical kernel : evidence from chronic schizophrenia outpatients

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dc.contributor.author Płonka, Olga [USOS175286] pl
dc.contributor.author Krześniak, Alicja pl
dc.contributor.author Adamczyk, Przemysław [SAP14029233] pl
dc.date.accessioned 2020-06-18T17:49:35Z
dc.date.available 2020-06-18T17:49:35Z
dc.date.issued 2020 pl
dc.identifier.uri https://ruj.uj.edu.pl/xmlui/handle/item/157693
dc.language eng pl
dc.rights Udzielam licencji. Uznanie autorstwa - Użycie niekomercyjne - Bez utworów zależnych 4.0 Międzynarodowa *
dc.rights.uri http://creativecommons.org/licenses/by-nc-nd/4.0/pl/legalcode *
dc.title Analysis of local gyrification index using a novel shape-adaptive kernel and the standard FreeSurfer spherical kernel : evidence from chronic schizophrenia outpatients pl
dc.type JournalArticle pl
dc.abstract.en Schizophrenia can be considered a brain disconnectivity condition related to aberrant neurodevelopment that causes alterations in the brain structure, including gyrification of the cortex. Literature findings on cortical folding are incoherent: they report hypogyria in the frontal, superior-parietal and temporal cortices, but also frontal hypergyria. This discrepancy in local gyrification index (LGI) results could be due to the commonly used spherical kernel (Freesurfer), which is a method of analysis that is still not spatially precise enough. In this study we would like to test the spatial accuracy of a novel method based on a shape-adaptive kernel (Cmorph). The analysis of differences in gyrification between chronic schizophrenia outpatients (n = 30) and healthy controls (n = 30) was conducted with two methods: Freesurfer LGI and Cmorph LGI. Widespread differences in the LGI between schizophrenia outpatients and healthy controls were found using both methods. Freesurfer showed hypogyria in the superior temporal gyrus and the right temporal pole; it also showed hypergyria in the rostral-middle-frontal cortex in schizophrenia outpatients. In comparison, Cmorph revealed that hypergyria is equally represented as hypogyria in orbitofrontal and central brain regions. The clusters from Cmorph were smaller and distributed more broadly, covering all lobes of the brain. The presented evidence from disrupted cortical folding in schizophrenia indicates that the shape-adaptive kernel approach has a potential to improve the knowledge on the disrupted cortical folding in schizophrenia; therefore, it could be a valuable tool for further investigation on big sample size. pl
dc.subject.en neuroscience pl
dc.subject.en nervous system pl
dc.subject.en neuroanatomy pl
dc.subject.en mental disorder pl
dc.subject.en clinical psychology pl
dc.subject.en mental health pl
dc.subject.en psychological disorders pl
dc.subject.en adaptive kernel pl
dc.subject.en cmorph pl
dc.subject.en local gyrification index pl
dc.subject.en schizophrenia pl
dc.subject.en spherical kernel pl
dc.description.volume 6 pl
dc.description.number 6 pl
dc.identifier.doi 10.1016/j.heliyon.2020.e04172 pl
dc.identifier.eissn 2405-8440 pl
dc.title.journal Heliyon pl
dc.language.container eng pl
dc.participation Adamczyk, Przemysław: 50%; pl
dc.affiliation Wydział Filozoficzny : Instytut Psychologii pl
dc.affiliation Szkoła Doktorska Nauk Społecznych pl
dc.subtype Article pl
dc.identifier.articleid e04172 pl
dc.rights.original CC-BY-NC-ND; otwarte czasopismo; ostateczna wersja wydawcy; w momencie opublikowania; 0 pl
dc.identifier.project ROD UJ / OP pl
.pointsMNiSW [2020 A]: 40


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Udzielam licencji. Uznanie autorstwa - Użycie niekomercyjne - Bez utworów zależnych 4.0 Międzynarodowa Except where otherwise noted, this item's license is described as Udzielam licencji. Uznanie autorstwa - Użycie niekomercyjne - Bez utworów zależnych 4.0 Międzynarodowa