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New bilayer-coated microbead system for controlled release of 5-aminosalicylic acid
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Except where otherwise noted, this item's license is described as Udzielam licencji. Uznanie autorstwa - Użycie niekomercyjne 4.0 Międzynarodowa
New bilayer-coated microbead system for controlled release of 5-aminosalicylic acid
Bibliographic description
| title: | New bilayer-coated microbead system for controlled release of 5-aminosalicylic acid |
| author: | Karewicz Anna  , Łęgowik Joanna, Nowakowska Maria
|
| journal title: | Polymer Bulletin |
| volume: | 66 |
| issue: | 3 |
| date of publication : | 2011 |
| pages: | 433-443 |
| ISSN: |
0170-0839 |
| eISSN: |
1436-2449 |
| DOI: | |
| URL: |
https://link.springer.com/content/pdf/10.1007%2Fs00289-010-0370-2.pdf |
| date accessed: |
2019-03-28 |
| language: | English |
| journal language: | English |
| abstract in English: | A new bilayer-coated microbeads for oral delivery of 5-aminosalicylic acid (5-ASA) were prepared from naturally occurring polysaccharides via emulsification method. 5-ASA was successfully encapsulated in chitosan–λ-carrageenan-coated alginate microbeads. The morphology and sizes of microparticles were studied using optical microscopy and dynamic light scattering. Drug release profiles were followed using high-performance liquid chromatography (HPLC) with spectrophotometric detection. The effect of chitosan thin layer and chitosan–λ-carrageenan bilayer on the drug release was studied at pH values simulating these characteristic for stomach (pH = 1.2) and intestine (pH = 7.4). Chitosan layer slightly increased 5-ASA release at pH = 1.2, whereas double-layer external coating decreased the release rates. Due to the bilayer properties, the micro-carriers were additionally protected against acidic conditions of the stomach and drug release in the intestine could be better controlled. |
| keywords in English: | alginate, chitosan, λ-carrageenan, microparticles, drug delivery, ultrathin layers |
| affiliation: | Wydział Chemii : Zakład Chemii Fizycznej i Elektrochemii |
| type: | journal article |
| subtype: | academic paper |
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Except where otherwise noted, this item's license is described as Udzielam licencji. Uznanie autorstwa - Użycie niekomercyjne 4.0 Międzynarodowa
Projekt „Repozytorium otwartego dostępu do dorobku naukowego i dydaktycznego UJ” współfinansowany w ramach poddziałania 2.3.1 „Cyfrowe udostępnianie zasobów nauki” Programu Operacyjnego Polska Cyfrowa z Europejskiego Funduszu Rozwoju Regionalnego i budżetu państwa na podstawie umowy o dofinansowanie nr POPC.02.03.01-00-0030/17-00
