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Increased expression of selected very late antigen integrin subunits on CD4 and CD8 blood T lymphocytes in patients with clinically stable asymptomatic atopic asthma
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Increased expression of selected very late antigen integrin subunits on CD4 and CD8 blood T lymphocytes in patients with clinically stable asymptomatic atopic asthma
Bibliographic description
| title: | Increased expression of selected very late antigen integrin subunits on CD4 and CD8 blood T lymphocytes in patients with clinically stable asymptomatic atopic asthma |
| author: | Bazan-Socha Stanisława  , Żuk Joanna , Musiał Jacek
|
| journal title: | Postępy Dermatologii i Alergologii |
| volume: | 29 |
| issue: | 5 |
| date of publication : | 2012 |
| pages: | 337-342 |
| ISSN: |
1642-395X |
| eISSN: |
2299-0046 |
| DOI: | |
| URL: | |
| date accessed: |
2020-06-03 |
| notes: | Bibliogr. s. 341-342 |
| language: | English |
| journal language: | English |
| abstract in English: | Recruitment of the inflammatory cells from blood to the airways in asthma is mediated by adhesive molecules, e.g. selectins and integrins. The most important integrins in cells trafficking are molecules containing $\alpha_{4}$ and $\beta_{2}$ subunits. We hypothesized that also $\alpha_{1}\beta_{1}$ and $\alpha_{2}\beta_{1}$ integrins (both found by us on blood eosinophils. To assess the expression of selected very late antigen (VLA) subunits ($\alpha_{1}$, $\alpha_{2}$, $\alpha_{4}$ and $\beta_{1}$) on blood CD4 and CD8 T lymphocytes from stable atopic asthmatic patients. of asthmatic subjects) are important in asthma pathogenesis. The study was conducted on 25 adult atopic asthmatics (mild to moderate persistent asthma in a stable clinical condition) and 17 matched healthy controls using flow cytometry. Expression of $\alpha_{4}$ and $\beta_{1}$ on CD4 T cells was significantly higher in asthma than in controls. The $\alpha_{1}$ subunit was absent from blood lymphocytes. The $\alpha_{2}$ chain hardly detected on lymphocytes from healthy subjects was distinctively present in asthmatics. Surprisingly, in subjects suffering from asthma for longer than 4 years (n = 15), the overexpression of $\alpha_{2}$, $\alpha_{4}$ and $\beta_{1}$ was observed on both: CD4 and CD8 T cells. Expression of selected VLA subunits on blood T cells may depend on asthma duration. The biological role of $\alpha_{2}\beta_{1}$ integrin in asthma is unknown, but as it was described as a stimulator of collagen accumulation in the airways, $\alpha_{2}\beta_{1}$ integrin could be, at least in part, responsible for asthma airway remodelling. |
| keywords in English: | asthma, integrins, collagen receptors, airway remodelling, inflammation |
| affiliation: | Wydział Lekarski : Klinika Alergii i Immunologii, Wydział Lekarski : II Katedra Chorób Wewnętrznych im. Profesora Andrzeja Szczeklika |
| type: | journal article |
| subtype: | academic paper |
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Except where otherwise noted, this item's license is described as Udzielam licencji. Uznanie autorstwa - Użycie niekomercyjne - Na tych samych warunkach 4.0 Międzynarodowa
Projekt „Repozytorium otwartego dostępu do dorobku naukowego i dydaktycznego UJ” współfinansowany w ramach poddziałania 2.3.1 „Cyfrowe udostępnianie zasobów nauki” Programu Operacyjnego Polska Cyfrowa z Europejskiego Funduszu Rozwoju Regionalnego i budżetu państwa na podstawie umowy o dofinansowanie nr POPC.02.03.01-00-0030/17-00
