Increased expression of selected very late antigen integrin subunits on CD4 and CD8 blood T lymphocytes in patients with clinically stable asymptomatic atopic asthma
Increased expression of selected very late antigen integrin subunits on CD4 and CD8 blood T lymphocytes in patients with clinically stable asymptomatic atopic asthma
Increased expression of selected very late antigen integrin subunits on CD4 and CD8 blood T lymphocytes in patients with clinically stable asymptomatic atopic asthma
author:
Bazan-Socha Stanisława , Żuk Joanna , Musiał Jacek
Recruitment of the inflammatory cells from blood to the airways in asthma is mediated by adhesive
molecules, e.g. selectins and integrins. The most important integrins in cells trafficking are molecules containing
$\alpha_{4}$ and $\beta_{2}$ subunits. We hypothesized that also $\alpha_{1}\beta_{1}$ and $\alpha_{2}\beta_{1}$ integrins (both found by us on blood eosinophils. To assess the expression of selected very late antigen (VLA) subunits ($\alpha_{1}$, $\alpha_{2}$, $\alpha_{4}$ and $\beta_{1}$) on blood CD4 and CD8
T lymphocytes from stable atopic asthmatic patients.
of asthmatic subjects) are important in asthma pathogenesis. The study was conducted on 25 adult atopic asthmatics (mild to moderate persistent asthma in a stable clinical condition) and 17 matched healthy controls using flow cytometry. Expression of $\alpha_{4}$ and $\beta_{1}$ on CD4 T cells was significantly higher in asthma than in controls. The $\alpha_{1}$ subunit
was absent from blood lymphocytes. The $\alpha_{2}$ chain hardly detected on lymphocytes from healthy subjects was distinctively present in asthmatics. Surprisingly, in subjects suffering from asthma for longer than 4 years (n = 15),
the overexpression of $\alpha_{2}$, $\alpha_{4}$ and $\beta_{1}$ was observed on both: CD4 and CD8 T cells. Expression of selected VLA subunits on blood T cells may depend on asthma duration. The biological
role of $\alpha_{2}\beta_{1}$ integrin in asthma is unknown, but as it was described as a stimulator of collagen accumulation in
the airways, $\alpha_{2}\beta_{1}$ integrin could be, at least in part, responsible for asthma airway remodelling.
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