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Structure and conformation of Arg^{8} vasopressin modified analogs

Structure and conformation of Arg^{8} vasopressin ...

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dc.contributor.author Proniewicz, Edyta [SAP11017634] pl
dc.contributor.author Sobolewski, Dariusz pl
dc.contributor.author Prahl, Adam pl
dc.contributor.author Kim, Younkyoo pl
dc.contributor.author Proniewicz, Leonard [SAP11008736] pl
dc.date.accessioned 2015-09-16T14:44:59Z
dc.date.available 2015-09-16T14:44:59Z
dc.date.issued 2012 pl
dc.identifier.issn 0377-0486 pl
dc.identifier.uri http://ruj.uj.edu.pl/xmlui/handle/item/15698
dc.language eng pl
dc.title Structure and conformation of Arg^{8} vasopressin modified analogs pl
dc.type JournalArticle pl
dc.description.physical 51-60 pl
dc.description.additional Na publikacji autorka Proniewicz Edyta podpisana jako Podstawka-Proniewicz Edyta. pl
dc.abstract.en Fourier-transform Raman and infrared spectra were acquired for four arginine vasopressin (AVP) analogs contain- ing L -diphenylalanine (Dpa): [Dpa 2 ]AVP, [Cpa 1 ,Dpa 2 ]AVP, [Dpa 3 ]AVP, and [Cpa 1 ,Dpa 3 ]AVP (where Cpa denotes 1- mercaptocyclohexaneacetic acid). We compared and analyzed these spectra. In addition, the Raman spectra were compared to the corresponding surface-enhanced Raman scattering spectra recorded in an aqueous silver colloidal dispersion. Silver colloidal dispersions prepared by the simple borohydride reduction of silver nitrate were used as substrates. The geometry of these molecules etched on the silver surface was deduced from the observed changes in the intensity enhancement, breadth, and shift in wavenumber of the Raman bands in the spectra of the bound versus free species. Based on the obtained data, adsorption mechanisms were proposed for each case, and the suggested adsorbate structures were compared. All the molecules were thought to adsorb onto a silver surface via a phenyl ring, free electron pairs on the sulfur atom, and C Oand –CONH-bonds. However, the orientation of these fragments on the colloidal silver surface and the strength of the interactions withthissurfacearedifferent.For[Dpa 3 ]AVPand[Cpa 1 ,Dpa 3 ]AVP,astronginteractionamongthe – CCN-peptidefragmentand the colloidal silver surface occurs. pl
dc.subject.en arginine vasopressin (AVP) pl
dc.subject.en neuropeptides pl
dc.subject.en colloidal silver surfac pl
dc.subject.en surface-enhanced Raman scattering (SERS) pl
dc.subject.en vibrational spectroscopy pl
dc.description.volume 43 pl
dc.description.number 1 pl
dc.description.points 35 pl
dc.identifier.doi 10.1002/jrs.2986 pl
dc.identifier.eissn 1097-4555 pl
dc.title.journal Journal of Raman Spectroscopy pl
dc.language.container eng pl
dc.affiliation Wydział Chemii : Zakład Fizyki Chemicznej pl
dc.subtype Article pl
dc.rights.original bez licencji pl
.pointsMNiSW [2012 A]: 35

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