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Effect of hydrogen peroxide of bacterial origin on apoptosis and necrosis of gut mucosa epithelial cells as a possible pathomechanism of inflammatory bowel disease and cancer
Effect of hydrogen peroxide of bacterial origin on apoptosis and necrosis of gut mucosa epithelial cells as a possible pathomechanism of inflammatory bowel disease and cancer
Effect of hydrogen peroxide of bacterial origin on apoptosis and necrosis of gut mucosa epithelial cells as a possible pathomechanism of inflammatory bowel disease and cancer
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dc.type
JournalArticle
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dc.description.physical
55-60
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dc.description.additional
Na publikacji autorka Kyzioł Agnieszka podpisana jako Jańczyk Agnieszka.
A series of in vitro experiments was arranged to assess effects of different concentrations of $H_{2}O_{2}$ contained in bacterial cultures on apoptosis and necrosis of HT-29 line cells representing human gut epithelium. On the basis of cytofluorimetric assays it was possible to demonstrate that supernatant of the Lactobacillus strain producing hydrogen peroxide (L. delbrueckii CU/22) was able to induce both apoptosis and necrosis in human epithelial culture cells HT-29. Both effects were more prominent than those visible under influence of supernatant of the non-$H_{2}O_{2}$-producing Lactobacillus strain or chemically pure $H_{2}O_{2}$ at the same concentration used as a control. In the light of this study and also other reports on damaging effects of hydrogen peroxide and superoxide radicals of bacterial origin on colonic cells, commensal bacteria of the human gut producing $H_{2}O_{2}$ may be involved in pathomechanisms of IBD by perpetuating the inflammatory reaction and increasing apoptosis and necrosis. There is a promise that probiotic preparations containing Lactobacillus bacteria will be successful as adjunct therapy of IBD and it is, therefore, postulated to make a very careful selection of the Lactobacillus strains as candidates for probiotics indicated to ameliorate the course of IBD, before starting clinical trials.
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dc.description.volume
60
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dc.description.number
suppl. 6
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dc.identifier.eissn
1899-1505
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dc.title.journal
Journal of Physiology and Pharmacology
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dc.language.container
eng
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dc.date.accession
2015-09-01
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dc.affiliation
Wydział Lekarski : Zakład Bakteriologii,Ekologii Drobnoustrojów i Parazytologii
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dc.affiliation
Wydział Chemii : Zakład Chemii Nieorganicznej
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dc.subtype
Article
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dc.rights.original
OTHER; otwarte czasopismo; ostateczna wersja wydawcy; w momencie opublikowania; 0;
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