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Effect of hydrogen peroxide of bacterial origin on apoptosis and necrosis of gut mucosa epithelial cells as a possible pathomechanism of inflammatory bowel disease and cancer

Effect of hydrogen peroxide of bacterial origin on ...

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dc.contributor.author Strus, Magdalena [SAP20008032] pl
dc.contributor.author Kyzioł, Agnieszka [SAP11019297] pl
dc.contributor.author Gonet-Surówka, Agnieszka [SAP14011137] pl
dc.contributor.author Brzychczy-Włoch, Monika [SAP20002305] pl
dc.contributor.author Stochel, Grażyna [SAP11011061] pl
dc.contributor.author Kochan, Piotr [SAP20002273] pl
dc.contributor.author Heczko, Piotr [SAP20000595] pl
dc.date.accessioned 2015-09-14T10:41:29Z
dc.date.available 2015-09-14T10:41:29Z
dc.date.issued 2009 pl
dc.identifier.issn 0867-5910 pl
dc.identifier.uri http://ruj.uj.edu.pl/xmlui/handle/item/15623
dc.language eng pl
dc.title Effect of hydrogen peroxide of bacterial origin on apoptosis and necrosis of gut mucosa epithelial cells as a possible pathomechanism of inflammatory bowel disease and cancer pl
dc.type JournalArticle pl
dc.description.physical 55-60 pl
dc.description.additional Na publikacji autorka Kyzioł Agnieszka podpisana jako Jańczyk Agnieszka. pl
dc.identifier.weblink http://www.jpp.krakow.pl/journal/archive/12_09_s6/pdf/55_12_09_s6_article.pdf pl
dc.abstract.en A series of in vitro experiments was arranged to assess effects of different concentrations of H2O2 contained in bacterial cultures on apoptosis and necrosis of HT-29 line cells representing human gut epithelium. On the basis of cytofluorimetric assays it was possible to demonstrate that supernatant of the Lactobacillus strain producing hydrogen peroxide (L. delbrueckii CU/22) was able to induce both apoptosis and necrosis in human epithelial culture cells HT-29. Both effects were more prominent than those visible under influence of supernatant of the non-H2O2-producing Lactobacillus strain or chemically pure H2O2 at the same concentration used as a control. In the light of this study and also other reports on damaging effects of hydrogen peroxide and superoxide radicals of bacterial origin on colonic cells, commensal bacteria of the human gut producing H2O2 may be involved in pathomechanisms of IBD by perpetuating the inflammatory reaction and increasing apoptosis and necrosis. There is a promise that probiotic preparations containing Lactobacillus bacteria will be successful as adjunct therapy of IBD and it is, therefore, postulated to make a very careful selection of the Lactobacillus strains as candidates for probiotics indicated to ameliorate the course of IBD, before starting clinical trials. pl
dc.description.volume 60 pl
dc.description.number suppl. 6 pl
dc.identifier.eissn 1899-1505 pl
dc.title.journal Journal of Physiology and Pharmacology pl
dc.language.container eng pl
dc.date.accession 2015-09-01 pl
dc.affiliation Wydział Lekarski : Zakład Bakteriologii,Ekologii Drobnoustrojów i Parazytologii pl
dc.affiliation Wydział Chemii : Zakład Chemii Nieorganicznej pl
dc.subtype Article pl
dc.rights.original OTHER; otwarte czasopismo; ostateczna wersja wydawcy; w momencie opublikowania; 0; pl


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