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Effect of hydrogen peroxide of bacterial origin on apoptosis and necrosis of gut mucosa epithelial cells as a possible pathomechanism of inflammatory bowel disease and cancer
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Effect of hydrogen peroxide of bacterial origin on apoptosis and necrosis of gut mucosa epithelial cells as a possible pathomechanism of inflammatory bowel disease and cancer
Bibliographic description
| title: | Effect of hydrogen peroxide of bacterial origin on apoptosis and necrosis of gut mucosa epithelial cells as a possible pathomechanism of inflammatory bowel disease and cancer |
| author: | Strus Magdalena  , Kyzioł Agnieszka , Gonet-Surówka Agnieszka , Brzychczy-Włoch Monika , Stochel Grażyna , Kochan Piotr , Heczko Piotr
|
| journal title: | Journal of Physiology and Pharmacology |
| volume: | 60 |
| issue: | suppl. 6 |
| date of publication : | 2009 |
| pages: | 55-60 |
| ISSN: |
0867-5910 |
| eISSN: |
1899-1505 |
| URL: |
http://www.jpp.krakow.pl/journal/archive/12_09_s6/pdf/55_12_09_s6_article.pdf |
| date accessed: |
2015-09-01 |
| notes: | Na publikacji autorka Kyzioł Agnieszka podpisana jako Jańczyk Agnieszka. |
| language: | English |
| journal language: | English |
| abstract in English: | A series of in vitro experiments was arranged to assess effects of different concentrations of H2O2 contained in bacterial cultures on apoptosis and necrosis of HT-29 line cells representing human gut epithelium. On the basis of cytofluorimetric assays it was possible to demonstrate that supernatant of the Lactobacillus strain producing hydrogen peroxide (L. delbrueckii CU/22) was able to induce both apoptosis and necrosis in human epithelial culture cells HT-29. Both effects were more prominent than those visible under influence of supernatant of the non-H2O2-producing Lactobacillus strain or chemically pure H2O2 at the same concentration used as a control. In the light of this study and also other reports on damaging effects of hydrogen peroxide and superoxide radicals of bacterial origin on colonic cells, commensal bacteria of the human gut producing H2O2 may be involved in pathomechanisms of IBD by perpetuating the inflammatory reaction and increasing apoptosis and necrosis. There is a promise that probiotic preparations containing Lactobacillus bacteria will be successful as adjunct therapy of IBD and it is, therefore, postulated to make a very careful selection of the Lactobacillus strains as candidates for probiotics indicated to ameliorate the course of IBD, before starting clinical trials. |
| affiliation: | Wydział Lekarski : Zakład Bakteriologii,Ekologii Drobnoustrojów i Parazytologii, Wydział Chemii : Zakład Chemii Nieorganicznej |
| type: | journal article |
| subtype: | academic paper |
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Projekt „Repozytorium otwartego dostępu do dorobku naukowego i dydaktycznego UJ” współfinansowany w ramach poddziałania 2.3.1 „Cyfrowe udostępnianie zasobów nauki” Programu Operacyjnego Polska Cyfrowa z Europejskiego Funduszu Rozwoju Regionalnego i budżetu państwa na podstawie umowy o dofinansowanie nr POPC.02.03.01-00-0030/17-00
