Schwannoma is a benign tumour originating from Schwann cells forming
sheaths of peripheral nerves. Its location in the oral cavity, and particularly in
the cheek, is very rare. A large tumour (5 cm) was surgically removed from
the left cheek of a fifty-five-year-old man and pathological examination revealed
schwannoma with Antoni A and B patterns. The tumour was investigated
using immunofluorescence and histochemical stainings. It showed positive
immunostaining for S-100, PGP 9.5, NSE, collagen IV, laminin, merosin and
vimentin. No immunofluorescence for GFAP, NPY and CGRP was observed.
Cells of the macrophage family (CD68-immunopositive) were scattered in
the connective tissue. Neither B (CD20+) nor T (CD3+, CD8+) lymphocytes
were found. The capillary network was revealed by CD34 immunostaining.
SMA immunoreactivity was observed in walls of larger blood vessels but not in
tumour cells. The tumour contained numerous mast cells visualized by thionin
staining and an abundance of collagen fibres revealed by picrosirius red.
affiliation:
Wydział Lekarski : Zakład Histologii, Wydział Lekarski : Zakład Neuropatologii
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