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Application of microextraction by packed sorbent to isolation of psychotropic drugs from human serum

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Application of microextraction by packed sorbent to isolation of psychotropic drugs from human serum

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dc.contributor.author Wietecha-Posłuszny, Renata [SAP11018414] pl
dc.contributor.author Garbacik, Aneta pl
dc.contributor.author Woźniakiewicz, Michał [SAP11019917] pl
dc.contributor.author Moos-Matysik, Agnieszka [SAP14004021] pl
dc.contributor.author Wieczorek, Marcin [SAP11019442] pl
dc.contributor.author Kościelniak, Paweł [SAP11010982] pl
dc.date.accessioned 2015-09-03T09:50:34Z
dc.date.available 2015-09-03T09:50:34Z
dc.date.issued 2012 pl
dc.identifier.issn 1618-2642 pl
dc.identifier.uri http://ruj.uj.edu.pl/xmlui/handle/item/15320
dc.language eng pl
dc.rights Udzielam licencji. Uznanie autorstwa - Użycie niekomercyjne 4.0 Międzynarodowa *
dc.rights.uri http://creativecommons.org/licenses/by-nc/4.0/pl/legalcode *
dc.title Application of microextraction by packed sorbent to isolation of psychotropic drugs from human serum pl
dc.type JournalArticle pl
dc.description.physical 2249-2257 pl
dc.description.additional Na publikacji autorka Moos-Matysik Agnieszka podpisana jako Moos Agnieszka. pl
dc.identifier.weblink https://link.springer.com/content/pdf/10.1007%2Fs00216-011-5442-0.pdf pl
dc.abstract.en A method of microextraction by packed sorbent (MEPS) followed by liquid chromatography with diode array detection has been developed and optimized for the extraction of six tricyclic antidepressants (amitriptyline, nortriptyline, imipra- mine, desipramine, doxepin, nordoxepin) from human serum. The optimal parameters of MEPS extraction (type of sorbent, volume of sample, composition, and volume of washing and elution solutions) for these drugs in spiked samples were defined. The developed MEPS procedure was validated and then successfully applied to the analysis of serum reference material. The limit of detection (0.02 – 0.05 μ g/mL), intraday (2.7 – 8.8%) and interday (4.4 – 11.6%) precision (RSD), and the accuracy of the assay (94.5 – 108.8%) at three concentration levels — 0.2, 0.5, and 0.8 μ g/mL — were estimated. The accuracy of the method was evaluated by the analysis of certified reference material. Moreover, the validated procedure was compared with the solid-phase extraction technique. Finally, microextraction by packed sorbent was assessed as a suitable tool in forensic and clinical methods for serum sample preparations. pl
dc.subject.en tricyclic antidepressant drugs pl
dc.subject.en solid-phase extraction pl
dc.subject.en microextraction by packed sorbent pl
dc.subject.en high-performance liquid chromatography pl
dc.subject.en human serum samples pl
dc.description.volume 402 pl
dc.description.number 7 pl
dc.description.points 35 pl
dc.identifier.doi 10.1007/s00216-011-5442-0 pl
dc.identifier.eissn 1618-2650 pl
dc.title.journal Analytical and Bioanalytical Chemistry pl
dc.language.container eng pl
dc.date.accession 2018-07-12 pl
dc.affiliation Wydział Chemii : Zakład Chemii Analitycznej pl
dc.subtype Article pl
dc.rights.original CC-BY-NC; inne; ostateczna wersja wydawcy; w momencie opublikowania; 0 pl
dc.identifier.project ROD UJ / P pl
.pointsMNiSW [2012 A]: 35


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Udzielam licencji. Uznanie autorstwa - Użycie niekomercyjne 4.0 Międzynarodowa Except where otherwise noted, this item's license is described as Udzielam licencji. Uznanie autorstwa - Użycie niekomercyjne 4.0 Międzynarodowa