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Influence of tobacco smoke on the pharmacokinetics of citalopram and its enantiomers
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Influence of tobacco smoke on the pharmacokinetics of citalopram and its enantiomers
Bibliographic description
| title: | Influence of tobacco smoke on the pharmacokinetics of citalopram and its enantiomers |
| author: | Majcherczyk Jagoda  , Kulza Maksymilian, Seńczuk-Przybyłowska Monika, Florek Ewa, Jawień Wojciech , Piekoszewski Wojciech
|
| journal title: | Journal of Physiology and Pharmacology |
| volume: | 63 |
| issue: | 1 |
| date of publication : | 2012 |
| pages: | 95-100 |
| ISSN: |
0867-5910 |
| eISSN: |
1899-1505 |
| URL: |
http://jpp.krakow.pl/journal/archive/02_12/pdf/95_02_12_article.pdf |
| date accessed: |
2015-09-03 |
| language: | English |
| journal language: | English |
| abstract in English: | The purpose of this study was to evaluate the influence of tobacco smoke on the pharmacokinetics of citalopram (CIT) and desmethylcitalopram (DCIT) and its enantiomers on an animal model. High performance liquid chromatography (HPLC) with a diode array detector (DAD) was used for the identification and quantification of the studied compounds. The HPLC quantification of racemic mixtures of CIT was performed on a C18 column. The limits of detection (LOD) and quantification (LOQ) were: 7 and 10 ng/ml respectively. HPLC separation of citalopram enantiomers (S- and R-CIT) was performed on a Chirobiotic V column. The limits of detection (LOD) and quantification (LOQ) were: 6 and 15 ng/ml for R- and S-CIT respectively. The experiment was carried out on male Wistar rats. The rats were exposed to tobacco smoke for five days (6 hours per day). After the exposure, citalopram was administered in a dose of 10 mg/kg intragastrically. In the control group (non-exposed animals), citalopram was administered in the same way and at an equal dose. The blood of the animals was collected at nine time points. It was found that tobacco smoke exposure inhibits the biotransformation of citalopram. The half-life of the racemic mixture of citalopram after intragastric administration was increased by about 287%. Changes in the pharmacokinetic parameters of S-citalopram (active isomer) show a similar tendency to those of the racemic mixture. The pharmacokinetics of R-citalopram showed no statistically important differences after tobacco smoke exposure. Alterations in the pharmacological parameters of desmethylcitalopram presented an opposite trend to the parent drug. After exposure to tobacco smoke, the induction of metabolism of this compound was observed. |
| keywords in English: | citalopram,, pharmacokinetics,, desmethylcitalopram,, selective serotonin reuptake inhibitors,, enantiomers,, tobacco smoking, high performance liquid chromatography |
| departmental parameterization: | 25 |
| affiliation: | Wydział Chemii : Zakład Chemii Analitycznej, Wydział Farmaceutyczny : Zakład Farmakokinetyki i Farmacji Fizycznej |
| type: | journal article |
| subtype: | academic paper |
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Projekt „Repozytorium otwartego dostępu do dorobku naukowego i dydaktycznego UJ” współfinansowany w ramach poddziałania 2.3.1 „Cyfrowe udostępnianie zasobów nauki” Programu Operacyjnego Polska Cyfrowa z Europejskiego Funduszu Rozwoju Regionalnego i budżetu państwa na podstawie umowy o dofinansowanie nr POPC.02.03.01-00-0030/17-00
