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Nanostructural hybrid sensitizers for photodynamic therapy

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Nanostructural hybrid sensitizers for photodynamic therapy

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dc.contributor.author Kępczyński, Mariusz [SAP11015411] pl
dc.contributor.author Dzieciuch-Rojek, Monika [USOS987] pl
dc.contributor.author Nowakowska, Maria [SAP11005597] pl
dc.date.accessioned 2015-08-27T06:16:38Z
dc.date.available 2015-08-27T06:16:38Z
dc.date.issued 2012 pl
dc.identifier.issn 1381-6128 pl
dc.identifier.uri http://ruj.uj.edu.pl/xmlui/handle/item/15076
dc.language eng pl
dc.title Nanostructural hybrid sensitizers for photodynamic therapy pl
dc.type JournalArticle pl
dc.description.physical 2607-2621 pl
dc.description.additional Na publikacji autorka Dzieciuch-Rojek Monika podpisana jako Dzieciuch Monika. pl
dc.identifier.weblink http://www.eurekaselect.com/97300/article pl
dc.abstract.en Photodynamic therapy (PDT) is a clinically approved method for treatment of cancer, microbial infections, and some other diseases. PDT has proved effective in the treatment of malignancies of various organs, including lung, bladder, gastrointestinal tract, and skin, and in the therapy of bacterial infection of skin wounds and carious lesions. It employs a combination of light and a drug (photosensitizer, PS) to induce phototoxicity against cancerous cells or bacteria. The efficiency of currently used PSs is limited due to their hydrophobic nature, which causes aggregation of the PS in aqueous media and low tumor selectivity (a low value of the tumor-to-normal tissue ratio). The purpose of this review is to present some aspects of the current state of knowledge on nanostructural carriers for the PS delivery. In this paper we reviewed studies on the development of nanostructural materials for PDT, especially those based on the polymeric and liposomal formulation of PS. We focused mainly on the nanostructural PSs obtained by the covalent attachment of hydrophilic polymer chain to the low-molecular-weight PS, the incorporation of PS into polymeric nanostructures such as micelles, and the solubilization of PS in liposome carriers pl
dc.subject.en Photodynamic therapy pl
dc.subject.en antibacterial treatment pl
dc.subject.en tumor cells, pl
dc.subject.en polymeric photosensitizers pl
dc.subject.en poly(ethylene glycol) pl
dc.subject.en polymeric photosensitizers pl
dc.subject.en porphyrins pl
dc.description.volume 18 pl
dc.description.number 18 pl
dc.description.points 40 pl
dc.identifier.doi 10.2174/138161212800492877 pl
dc.identifier.eissn 1873-4286 pl
dc.title.journal Current Pharmaceutical Design pl
dc.language.container eng pl
dc.date.accession 2018-11-29 pl
dc.affiliation Wydział Chemii : Zakład Chemii Fizycznej i Elektrochemii pl
dc.subtype Article pl
dc.rights.original OTHER; inne; ostateczna wersja wydawcy; w momencie opublikowania; 0 pl
.pointsMNiSW [2012 A]: 40


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