Jagiellonian University Repository
Lupane-type pentacyclic triterpenes in langmuir monolayers : a synchrotron radiation scattering study
Communities & Collections
pcg.skipToMenu
Lupane-type pentacyclic triterpenes in langmuir monolayers : a synchrotron radiation scattering study
Bibliographic description
| title: | Lupane-type pentacyclic triterpenes in langmuir monolayers : a synchrotron radiation scattering study |
| author: | Broniatowski Marcin  , Flasiński Michał , Wydro Paweł
|
| journal title: | Langmuir |
| volume: | 28 |
| issue: | 11 |
| date of publication : | 2012 |
| pages: | 5201-5210 |
| ISSN: |
0743-7463 |
| eISSN: |
1520-5827 |
| DOI: | |
| language: | English |
| journal language: | English |
| abstract in English: | Lupane-type pentacyclic triterpenes (lupeol, betulin, and betulinic acid) are natural products isolated from various plant sources. The terpenes exhibit a vast spectrum of biological activity and are applied in therapies for different diseases, among which the anticancer, anti-HIV, antihypercholest eremic, and antiinflammatory are the most promising. These chemicals possess amphiphilic structure and were proved to interact strongly with biomembranes, which can be the key stage in their mechanism of action. In our studies, we applied Langmuir monolayers as versatile models of biomembranes. It turned out that the three investigated terpenes are capable of stable monolayer formation; however, these monolayers differ profoundly regarding their physicochemical character- istics. In our research, we applied the Langmuir technique (surface pressure − mean molecular area ( π − A) isotherm registration) coupled with Brewster angle microscopy (BAM), but the main focus was on the synchrotron radiation scattering method, grazing incidence X-ray diffraction (GIXD), which provides information on the amphiphilic molecule ordering in the angstro m scale. It was proved that all the investigated terpenes form crystalline phases in their monolayers. In the case of lupeol, only the closely packed upright phase was observed, whereas for betulin and betulinic acid, the phase situation was more complex. Betulinic acid molecules can be organized in an upright phase, which is crystalline, and in a tilted phase, which is amorphous. The betulin film is a conglomerate of an upright crystalline monolayer phase, tilted amorphous monolayer phase, and a crystalline tilted bilayer. In our paper, we discuss the factors leading to the formation of the observed phases and the implications of our results to the therapeutic applications of the native lupane- type triterpenes. |
| departmental parameterization: | 35 |
| affiliation: | Wydział Chemii : Zakład Chemii Fizycznej i Elektrochemii, Wydział Chemii : Zakład Chemii Środowiska |
| type: | journal article |
| subtype: | academic paper |
Files in this item
| Files | Size | Format | View |
|---|---|---|---|
|
There are no files associated with this item. |
|||
This item appears in the following Collection(s)
Projekt „Repozytorium otwartego dostępu do dorobku naukowego i dydaktycznego UJ” współfinansowany w ramach poddziałania 2.3.1 „Cyfrowe udostępnianie zasobów nauki” Programu Operacyjnego Polska Cyfrowa z Europejskiego Funduszu Rozwoju Regionalnego i budżetu państwa na podstawie umowy o dofinansowanie nr POPC.02.03.01-00-0030/17-00
