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Fuzzy oil drop model to interpret the structure of antifreeze proteins and their mutants
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Fuzzy oil drop model to interpret the structure of antifreeze proteins and their mutants
Bibliographic description
| title: | Fuzzy oil drop model to interpret the structure of antifreeze proteins and their mutants |
| author: | Banach Mateusz  , Prymula Katarzyna , Jurkowski Wiktor, Konieczny Leszek, Roterman-Konieczna Irena
|
| journal title: | Journal of Molecular Modeling |
| volume: | 18 |
| issue: | 1 |
| date of publication : | 2012 |
| pages: | 229-237 |
| ISSN: |
1610-2940 |
| eISSN: |
0948-5023 |
| DOI: | |
| language: | English |
| journal language: | English |
| abstract in English: | Mutations in proteins introduce structural changes and influence biological activity: the specific effects depend on the location of the mutation. The simple method proposed in the present paper is based on a two- step model of in silico protein folding. The structure of the first intermediate is assumed to be determined solely by backbone conformation. The structure of the second one is assumed to be determined by the presence of a hydrophobic center. The comparable structural analysis of the set of mutants is performed to id entify the mutant-induced structural changes. The changes of the hydrophobic core organization measured by the divergence entropy allows quantitative comparison estimating the relative structural changes upon mutation. The set of antifreeze proteins, which appeared to represent the hydrophobic core structure accordant with “ fuzzy oil drop ” model was selected for analysis |
| keywords in English: | antifreeze, intermediates, hydrophobicity, protein structure, mutants |
| departmental parameterization: | 25 |
| affiliation: | Wydział Lekarski : Zakład Bioinformatyki i Telemedycyny, Wydział Chemii, Wydział Fizyki, Astronomii i Informatyki Stosowanej |
| type: | journal article |
| subtype: | academic paper |
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Projekt „Repozytorium otwartego dostępu do dorobku naukowego i dydaktycznego UJ” współfinansowany w ramach poddziałania 2.3.1 „Cyfrowe udostępnianie zasobów nauki” Programu Operacyjnego Polska Cyfrowa z Europejskiego Funduszu Rozwoju Regionalnego i budżetu państwa na podstawie umowy o dofinansowanie nr POPC.02.03.01-00-0030/17-00
