Jagiellonian University Repository
Age-dependent determinants of infectious complications profile in children and adults after hematopoietic cell transplantation : lesson from the nationwide study
Communities & Collections
pcg.skipToMenu
Except where otherwise noted, this item's license is described as Udzielam licencji. Uznanie autorstwa 4.0 Międzynarodowa
Age-dependent determinants of infectious complications profile in children and adults after hematopoietic cell transplantation : lesson from the nationwide study
Bibliographic description
| title: | Age-dependent determinants of infectious complications profile in children and adults after hematopoietic cell transplantation : lesson from the nationwide study |
| author: | Czyżewski Krzysztof, Styczyński Jan, Giebel Sebastian, Frączkiewicz Jowita, Salamonowicz Małgorzata, Zając-Spychała Olga, Zaucha-Prażmo Agnieszka, Drozd-Sokołowska Joanna, Waszczuk-Gajda Anna, Dybko Jarosław, Mańko Joanna, Zalas-Więcek Patrycja, Gałązka Przemysław, Wysocki Mariusz, Kowalczyk Jerzy R., Wachowiak Jacek, Goździk Jolanta  , Basak Grzegorz W., Kałwak Krzysztof, Adamska Monika, Hus Marek, Piekarska Agnieszka, Sadowska-Klasa Alicja, Mensah-Glanowska Patrycja , Kyrcz-Krzemień Sławomira, Biernat Monika, Wierzbowska Agnieszka, Rzepecki Piotr, Tomaszewska Agnieszka, Hałaburda Kazimierz, Gil Lidia |
| journal title: | Annals of Hematology |
| volume: | 98 |
| issue: | 9 |
| date of publication : | 2019 |
| pages: | 2197-2211 |
| ISSN: |
0939-5555 |
| eISSN: |
1432-0584 |
| DOI: | |
| language: | English |
| journal language: | English |
| abstract in English: | Incidence and outcome of microbiologically documented bacterial/viral infections and invasive fungal disease (IFD) in children and adults after hematopoietic cell transplantation (HCT) were compared in 650 children and 3200 adults in multicenter cross-sectional nationwide study. Infections were diagnosed in 60.8% children and 35.0% adults, including respectively 69.1% and 63.5% allo-HCT, and 33.1% and 20.8% auto-HCT patients. The incidence of bacterial infections was higher in children (36.0% vs 27.6%; p < 0.0001). Infections with Gram-negative bacteria were more frequent than Gram-positives in adults (64.6% vs 44.8%; p < 0.0001). Outcome of bacterial infections was better in children (95.5% vs 91.4%; p = 0.0011). The IFD incidence (25.3% vs 6.3%; p < 0.0001) and outcome (88.0% vs 74.9%; p < 0.0001) were higher in children. The incidence of viral infections was higher in children after allo-HCT (56.3% vs 29.3%; p < 0.0001), and auto-HCT (6.6% vs 0.8%; p < 0.0001). Outcome of viral infections was better in children (98.6% vs 92.3%; p = 0.0096). Infection-related mortality was 7.8% in children and 18.4% in adults (p < 0.0001). No child after auto-HCT died of infection. Adult age, mismatched transplants, acute leukemia, chronic GVHD, CMV reactivation, infection with Gram-negatives, and duration of infection > 21 days were risk factors for death from infection. In conclusion, pediatric patients have 2.9-fold higher incidence and 2.5-fold better outcome of infections than adults after HCT. |
| keywords in English: | hematopoietic cell transplantation, children, adults, incidence, outcome, bacterial infections, viral infections, invasive fungal disease |
| departmental parameterization: | 70 |
| affiliation: | Wydział Lekarski : Instytut Pediatrii, Wydział Lekarski : Klinika Hematologii |
| type: | journal article |
| subtype: | academic paper |
Files in this item
This item appears in the following Collection(s)
Except where otherwise noted, this item's license is described as Udzielam licencji. Uznanie autorstwa 4.0 Międzynarodowa
Projekt „Repozytorium otwartego dostępu do dorobku naukowego i dydaktycznego UJ” współfinansowany w ramach poddziałania 2.3.1 „Cyfrowe udostępnianie zasobów nauki” Programu Operacyjnego Polska Cyfrowa z Europejskiego Funduszu Rozwoju Regionalnego i budżetu państwa na podstawie umowy o dofinansowanie nr POPC.02.03.01-00-0030/17-00
