Predictors of neutrophil extracellular traps markers in type 2 diabetes mellitus : associations with a prothrombotic state and hypofibrinolysis

doi:10.1186/s12933-019-0850-0

Predictors of neutrophil extracellular traps markers in type 2 diabetes mellitus : associations with a prothrombotic state and hypofibrinolysis

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Predictors of neutrophil extracellular traps markers in type 2 diabetes mellitus : associations with a prothrombotic state and hypofibrinolysis

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dc.contributor.author	Bryk, Agata [SAP20018038]	pl
dc.contributor.author	Prior, Shannon M.	pl
dc.contributor.author	Plens, Krzysztof	pl
dc.contributor.author	Konieczyńska, Małgorzata	pl
dc.contributor.author	Hohendorff, Jerzy [SAP20011665]	pl
dc.contributor.author	Małecki, Maciej [SAP20001383]	pl
dc.contributor.author	Butenas, Saulius	pl
dc.contributor.author	Undas, Anetta [SAP20001686]	pl
dc.date.accessioned	2020-01-17T10:07:59Z
dc.date.available	2020-01-17T10:07:59Z
dc.date.issued	2019	pl
dc.identifier.issn	1475-2840	pl
dc.identifier.uri	https://ruj.uj.edu.pl/xmlui/handle/item/146027
dc.language	eng	pl
dc.rights	Udzielam licencji. Uznanie autorstwa 4.0 Międzynarodowa	*
dc.rights.uri	http://creativecommons.org/licenses/by/4.0/pl/legalcode	*
dc.title	Predictors of neutrophil extracellular traps markers in type 2 diabetes mellitus : associations with a prothrombotic state and hypofibrinolysis	pl
dc.type	JournalArticle	pl
dc.abstract.en	Background Type 2 diabetes mellitus (T2DM) is associated with a hypercoagulable state and increased neutrophil extracellular traps formation (NETosis). We investigated predictors of NETosis and cell death markers in circulating blood and their association with a prothrombotic state in T2DM. Methods In a cross-sectional study involving 113 T2DM patients aged 63.7 ± 8.2 years, we investigated citrullinated histone H3 (H3Cit), cell-free deoxyribonucleic acid (cfDNA), myeloperoxidase, neutrophil elastase, and inflammation markers, along with thrombin generation (TG), plasma clot lysis time (CLT), clot permeability (Ks) and fibrinolysis inhibitors. Results On multivariate logistic regression analysis adjusted for age and gender, predictors of high H3Cit (≥ 7.36 ng/mL, upper quartile) were: glycated hemoglobin (HbA1c) ≥ 7.0% and interleukin-6. Interleukin-6 was also found to be a predictor of high cfDNA (≥ 2.84 µg/mL, upper quartile) along with glucose. Citrullinated histone H3 and cfDNA correlated positively with CLT and inversely with Ks, while TG associated solely with cfDNA. These associations were not seen with myeloperoxidase and neutrophil elastase. Patients with previous myocardial infarction (n = 21, 18.6%) had higher H3Cit (+108%, p < 0.001) and cfDNA (+45%, p = 0.022). On multivariable analysis adjusted for potential confounders, H3Cit and cfDNA, along with plasminogen activator inhibitor-1 and concomitant cardiovascular disease, were predictors of CLT. Citrullinated histone H3 alone was a predictor of Ks and only cfDNA was a predictor of peak thrombin generated. Conclusions In T2DM, NETosis detectable in circulating blood is associated with inflammatory state and a prothrombotic state, especially hypofibrinolysis.	pl
dc.subject.en	type 2 diabetes	pl
dc.subject.en	fibrinolysis	pl
dc.subject.en	neutrophil extracellular traps	pl
dc.subject.en	fibrin clot	pl
dc.subject.en	cardiovascular disease	pl
dc.description.volume	18	pl
dc.description.points	140	pl
dc.identifier.doi	10.1186/s12933-019-0850-0	pl
dc.identifier.eissn	1475-2840
dc.title.journal	Cardiovascular Diabetology	pl
dc.language.container	eng	pl
dc.affiliation	Wydział Lekarski : Instytut Kardiologii	pl
dc.affiliation	Wydział Lekarski : Klinika Chorób Metabolicznych	pl
dc.subtype	Article	pl
dc.identifier.articleid	49	pl
dc.rights.original	CC-BY; otwarte czasopismo; ostateczna wersja wydawcy; w momencie opublikowania; 0	pl
dc.identifier.project	ROD UJ / OP	pl
dc.cm.id	94035
dc.cm.date	2020-01-07
.pointsMNiSW	[2019 A]: 140