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Neuropeptide B and neuropeptide W as new serum predictors of nutritional status and of clinical outcomes in pediatric patients with type 1 diabetes mellitus treated with the use of pens or insulin pumps

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Neuropeptide B and neuropeptide W as new serum predictors of nutritional status and of clinical outcomes in pediatric patients with type 1 diabetes mellitus treated with the use of pens or insulin pumps

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dc.contributor.author Grzelak, Teresa pl
dc.contributor.author Wędrychowicz, Anna [SAP20001590] pl
dc.contributor.author Grupińska, Joanna pl
dc.contributor.author Pełczyńska, Marta pl
dc.contributor.author Sperling, Marcelina pl
dc.contributor.author Mikulska, Aniceta A. pl
dc.contributor.author Naughton, Violetta pl
dc.contributor.author Czyżewska, Krystyna pl
dc.date.accessioned 2020-01-17T10:07:53Z
dc.date.available 2020-01-17T10:07:53Z
dc.date.issued 2019 pl
dc.identifier.issn 1734-1922 pl
dc.identifier.uri https://ruj.uj.edu.pl/xmlui/handle/item/145855
dc.language eng pl
dc.rights Udzielam licencji. Uznanie autorstwa - Użycie niekomercyjne - Na tych samych warunkach 4.0 Międzynarodowa *
dc.rights.uri http://creativecommons.org/licenses/by-nc-sa/4.0/pl/legalcode *
dc.title Neuropeptide B and neuropeptide W as new serum predictors of nutritional status and of clinical outcomes in pediatric patients with type 1 diabetes mellitus treated with the use of pens or insulin pumps pl
dc.type JournalArticle pl
dc.description.physical 619-631 pl
dc.abstract.en Introduction: The aim of our study was to determine the relationship between neuropeptide B (NPB), neuropeptide W (NPW), nutritional and antioxidant status and selected fat- and bone-derived factors in type 1 diabetes mellitus (T1DM) treated using pens (T1DM pen group) or insulin pumps (T1DM pump group) in order to investigate the potential role of NPB and NPW in the clinical outcomes of T1DM. Material and methods: Fifty-eight patients with T1DM and twenty-five healthy controls (CONTR) participated in the study. Assessments of NPB, NPW, total antioxidant status (TAS), leptin, adiponectin, osteocalcin, and free soluble receptor activator for nuclear factor κB (free sRANKL) were conducted. Results: NPB, NPW, leptin, and TAS were lower (by 33%, p < 0.013; 34%, p < 0.008; 290%, p < 0.00004; 21%, p < 0.05; respectively), while adiponectin was by 51% higher (p < 0.006) in T1DM vs. CONTR, while osteocalcin and free sRANKL levels were similar in both groups. NPW was lower in the T1DM pen group both vs. the T1DM pump group (36% lower, p < 0.0009) and vs. the CONTR group (35% lower, p < 0.002). In the T1DM pen group, but not in the T1DM pump group or the CONTR group, the Cole index and TAS levels explain (besides NPB) the variation in NPW values. ROC curves showed that serum levels of leptin, adiponectin, NPB and NPW (but not osteocalcin or free sRANKL) were predictive indicators for T1DM. Conclusions: Measurements of NPB and NPW, besides leptin and adiponectin, are worth considering in the detailed prognosis of nutritional status in T1DM, primarily in the T1DM pen-treated population. pl
dc.subject.en insulin pl
dc.subject.en biochemistry pl
dc.subject.en type 1 diabetes mellitus pl
dc.description.volume 15 pl
dc.description.number 3 pl
dc.description.points 70 pl
dc.identifier.doi 10.5114/aoms.2018.75818 pl
dc.identifier.eissn 1896-9151 pl
dc.title.journal Archives of Medical Science pl
dc.language.container eng pl
dc.affiliation Wydział Lekarski : Instytut Pediatrii pl
dc.subtype Article pl
dc.rights.original CC-BY-NC-SA; otwarte czasopismo; ostateczna wersja wydawcy; w momencie opublikowania; 0 pl
dc.identifier.project ROD UJ / OP pl
dc.cm.id 93730
dc.cm.date 2020-01-07
.pointsMNiSW [2019 A]: 100


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Udzielam licencji. Uznanie autorstwa - Użycie niekomercyjne - Na tych samych warunkach 4.0 Międzynarodowa Except where otherwise noted, this item's license is described as Udzielam licencji. Uznanie autorstwa - Użycie niekomercyjne - Na tych samych warunkach 4.0 Międzynarodowa