Neuropeptide B and neuropeptide W as new serum predictors of nutritional status and of clinical outcomes in pediatric patients with type 1 diabetes mellitus treated with the use of pens or insulin pumps
Neuropeptide B and neuropeptide W as new serum predictors of nutritional status and of clinical outcomes in pediatric patients with type 1 diabetes mellitus treated with the use of pens or insulin pumps
Neuropeptide B and neuropeptide W as new serum predictors of nutritional status and of clinical outcomes in pediatric patients with type 1 diabetes mellitus treated with the use of pens or insulin pumps
author:
Grzelak Teresa, Wędrychowicz Anna , Grupińska Joanna, Pełczyńska Marta, Sperling Marcelina, Mikulska Aniceta A., Naughton Violetta, Czyżewska Krystyna
Introduction: The aim of our study was to determine the relationship between neuropeptide B (NPB), neuropeptide W (NPW), nutritional and antioxidant status and selected fat- and bone-derived factors in type 1 diabetes mellitus (T1DM) treated using pens (T1DM pen group) or insulin pumps
(T1DM pump group) in order to investigate the potential role of NPB and
NPW in the clinical outcomes of T1DM.
Material and methods: Fifty-eight patients with T1DM and twenty-five
healthy controls (CONTR) participated in the study. Assessments of NPB, NPW,
total antioxidant status (TAS), leptin, adiponectin, osteocalcin, and free soluble receptor activator for nuclear factor κB (free sRANKL) were conducted.
Results: NPB, NPW, leptin, and TAS were lower (by 33%, p < 0.013; 34%,
p < 0.008; 290%, p < 0.00004; 21%, p < 0.05; respectively), while adiponectin was by 51% higher (p < 0.006) in T1DM vs. CONTR, while osteocalcin and
free sRANKL levels were similar in both groups. NPW was lower in the T1DM
pen group both vs. the T1DM pump group (36% lower, p < 0.0009) and vs.
the CONTR group (35% lower, p < 0.002). In the T1DM pen group, but not in
the T1DM pump group or the CONTR group, the Cole index and TAS levels
explain (besides NPB) the variation in NPW values. ROC curves showed that
serum levels of leptin, adiponectin, NPB and NPW (but not osteocalcin or
free sRANKL) were predictive indicators for T1DM.
Conclusions: Measurements of NPB and NPW, besides leptin and adiponectin, are worth considering in the detailed prognosis of nutritional status in
T1DM, primarily in the T1DM pen-treated population.
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