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High soluble endoglin levels do not induce endothelial dysfunction in mouse aorta

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High soluble endoglin levels do not induce endothelial dysfunction in mouse aorta

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dc.contributor.author Nemeckova, Ivana pl
dc.contributor.author Serwadczak, Agnieszka [SAP14012916] pl
dc.contributor.author Oujo, Barbara pl
dc.contributor.author Jezkova, Katerina pl
dc.contributor.author Rathouska, Jana pl
dc.contributor.author Fikrova, Petra pl
dc.contributor.author Varejckova, Michala pl
dc.contributor.author Bernabeu, Carmelo pl
dc.contributor.author Lopez-Novoa, Jose M. pl
dc.contributor.author Chłopicki, Stefan [SAP20000969] pl
dc.contributor.author Nachtigal, Petr pl
dc.date.accessioned 2015-07-31T12:28:29Z
dc.date.available 2015-07-31T12:28:29Z
dc.date.issued 2015 pl
dc.identifier.uri http://ruj.uj.edu.pl/xmlui/handle/item/14368
dc.language eng pl
dc.rights Udzielam licencji. Uznanie autorstwa 4.0 Międzynarodowa *
dc.rights.uri http://creativecommons.org/licenses/by/4.0/pl/legalcode *
dc.title High soluble endoglin levels do not induce endothelial dysfunction in mouse aorta pl
dc.type JournalArticle pl
dc.description.physical [1-13] pl
dc.abstract.en Increased levels of a soluble form of endoglin (sEng) circulating in plasma have been detected in various pathological conditions related to cardiovascular system. High concentration of sEng was also proposed to contribute to the development of endothelial dysfunction, but there is no direct evidence to support this hypothesis. Therefore, in the present work we analyzed whether high sEng levels induce endothelial dysfunction in aorta by using transgenic mice with high expression of human sEng. Transgenic mice with high expression of human sEng on CBAxC57Bl/6J background (Sol-Eng+) and age-matched transgenic littermates that do not develop high levels of human soluble endoglin (control animals in this study) on chow diet were used. As expected, male and female Sol-Eng+ transgenic mice showed higher levels of plasma concentrations of human sEng as well as increased blood arterial pressure, as compared to control animals. Functional analysis either in vivo or ex vivo in isolated aorta demonstrated that the endothelium-dependent vascular function was similar in Sol-Eng+ and control mice. In addition, Western blot analysis showed no differences between Sol-Eng+ and control mice in the protein expression levels of endoglin, endothelial NO-synthase (eNOS) and pro-inflammatory ICAM-1 and VCAM-1 from aorta. Our results demonstrate that high levels of soluble endoglin alone do not induce endothelial dysfunction in Sol-Eng+ mice. However, these data do not rule out the possibility that soluble endoglin might contribute to alteration of endothelial function in combination with other risk factors related to cardiovascular disorders. pl
dc.description.volume 10 pl
dc.description.number 3 pl
dc.description.points 40 pl
dc.identifier.doi 10.1371/journal.pone.0119665 pl
dc.identifier.eissn 1932-6203 pl
dc.title.journal PLoS ONE pl
dc.language.container eng pl
dc.affiliation Wydział Lekarski : Zakład Farmakologii Doświadczalnej pl
dc.affiliation Pion Rektora : Jagiellońskie Centrum Rozwoju Leków pl
dc.subtype Article pl
dc.identifier.articleid e0119665 pl
dc.rights.original CC-BY; otwarte czasopismo; ostateczna wersja wydawcy; w momencie opublikowania; 0; pl
dc.identifier.project ROD UJ / P pl
dc.cm.id 72350
.pointsMNiSW [2015 A]: 40


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Udzielam licencji. Uznanie autorstwa 4.0 Międzynarodowa Except where otherwise noted, this item's license is described as Udzielam licencji. Uznanie autorstwa 4.0 Międzynarodowa