Follow-up of parenchymal changes in the thyroid gland with diffuse autoimmune thyroiditis in children prior to the development of papillary thyroid carcinoma

doi:10.1007/s40618-018-0909-x

Follow-up of parenchymal changes in the thyroid gland with diffuse autoimmune thyroiditis in children prior to the development of papillary thyroid carcinoma

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Follow-up of parenchymal changes in the thyroid gland with diffuse autoimmune thyroiditis in children prior to the development of papillary thyroid carcinoma

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dc.contributor.author	Januś, Dominika [SAP20001904]	pl
dc.contributor.author	Wójcik, Małgorzata [SAP20002615]	pl
dc.contributor.author	Taczanowska-Niemczuk, Anna [SAP20012686]	pl
dc.contributor.author	Sołtysiak, Piotr [SAP20014698]	pl
dc.contributor.author	Wędrychowicz, Anna [SAP20001590]	pl
dc.contributor.author	Roztoczyńska, Dorota	pl
dc.contributor.author	Drabik, Grażyna [SAP20002016]	pl
dc.contributor.author	Wyrobek, Łukasz	pl
dc.contributor.author	Starzyk, Jerzy [SAP20001067]	pl
dc.date.accessioned	2020-01-17T09:58:54Z
dc.date.available	2020-01-17T09:58:54Z
dc.date.issued	2019	pl
dc.identifier.issn	0391-4097	pl
dc.identifier.uri	https://ruj.uj.edu.pl/xmlui/handle/item/143357
dc.language	eng	pl
dc.rights	Udzielam licencji. Uznanie autorstwa 4.0 Międzynarodowa	*
dc.rights.uri	http://creativecommons.org/licenses/by/4.0/pl/legalcode	*
dc.title	Follow-up of parenchymal changes in the thyroid gland with diffuse autoimmune thyroiditis in children prior to the development of papillary thyroid carcinoma	pl
dc.type	JournalArticle	pl
dc.description.physical	261-270	pl
dc.abstract.en	Purpose To present the outcomes of ultrasound (US) follow-ups in children with autoimmune thyroid disease who did not have a thyroid nodule on admission but developed papillary thyroid carcinoma (PTC) and to characterize the parenchymal changes in the thyroid gland prior to the development of PTC. Methods A retrospective thyroid US scan review of 327 patients diagnosed with AIT was performed. Forty patients (40/327, 12.2%) presented nodular AIT variant with a normoechogenic background. Eleven patients (11/327, 3.4%, 11/40, 27.5%) presenting this variant were diagnosed with PTC (nine females-mean age 15.3 years; two males aged 11 and 13 years). In five of 11 patients, the suspicious nodule that was later confirmed to be PTC was detected on the initial US at presentation. For the remaining six females (6/11) who developed PTC during the follow-up, we retrospectively analysed their US thyroid scans and these patients were selected for analysis in this study. Results On admission, the US evaluation revealed an enlarged normoechogenic thyroid gland in three patients and a hypoechogenic thyroid gland with fibrosis as indicated by irregular, chaotic hyperechogenic layers in three patients. No thyroid nodules were identified. Ultrasound monitoring revealed increasing echogenicity of the thyroid parenchyma during the follow-up. PTC developed in a mean time of 4.6 years (1 9/12-7 4/12 years) since referral to the outpatient thyroid clinic and 2.9 years (6/12-6 9/12) since the last nodule-free US thyroid scan. Conclusions Sonographic follow-up assessments warrant further exploration as a strategy to determine PTC susceptibility in the paediatric population.	pl
dc.subject.en	autoimmune thyroiditis	pl
dc.subject.en	papillary thyroid carcinoma	pl
dc.subject.en	ultrasonography of thyroid gland	pl
dc.subject.en	normoechogenic background of thyroid gland	pl
dc.description.volume	42	pl
dc.description.number	3	pl
dc.description.points	100	pl
dc.identifier.doi	10.1007/s40618-018-0909-x	pl
dc.identifier.eissn	1720-8386
dc.title.journal	Journal of Endocrinological Investigation	pl
dc.language.container	eng	pl
dc.affiliation	Wydział Lekarski : Instytut Pediatrii	pl
dc.subtype	Article	pl
dc.rights.original	CC-BY; inne; ostateczna wersja wydawcy; w momencie opublikowania; 0	pl
dc.identifier.project	ROD UJ / OP	pl
dc.cm.id	89357
dc.cm.date	2020-01-07
.pointsMNiSW	[2019 A]: 100