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Tumor expression of survivin, p53, cyclin D1, osteopontin and fibronectin in predicting the response to neo-adjuvant chemotherapy in children with advanced malignant peripheral nerve sheath tumor

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Tumor expression of survivin, p53, cyclin D1, osteopontin and fibronectin in predicting the response to neo-adjuvant chemotherapy in children with advanced malignant peripheral nerve sheath tumor

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dc.contributor.author Karpinsky, Gabrielle pl
dc.contributor.author Krawczyk, Małgorzata A. pl
dc.contributor.author Izycka.Swieszewska, Ewa pl
dc.contributor.author Fatyga, Aleksandra pl
dc.contributor.author Budka, Agnieszka pl
dc.contributor.author Balwierz, Walentyna [SAP20001149] pl
dc.contributor.author Sobol, Grażyna pl
dc.contributor.author Zalewska-Szewczyk, Beata pl
dc.contributor.author Rychłowska-Pruszyńska, Magdalena pl
dc.contributor.author Klepacka, Teresa pl
dc.contributor.author Dembowska-Bagińska, Bożenna pl
dc.contributor.author Kazanowska, Bernarda pl
dc.contributor.author Gabrych, Anna pl
dc.contributor.author Bień, Ewa pl
dc.date.accessioned 2020-01-17T09:20:31Z
dc.date.available 2020-01-17T09:20:31Z
dc.date.issued 2018 pl
dc.identifier.issn 0171-5216 pl
dc.identifier.uri https://ruj.uj.edu.pl/xmlui/handle/item/142406
dc.language eng pl
dc.rights Udzielam licencji. Uznanie autorstwa 4.0 Międzynarodowa *
dc.rights.uri http://creativecommons.org/licenses/by/4.0/pl/legalcode *
dc.title Tumor expression of survivin, p53, cyclin D1, osteopontin and fibronectin in predicting the response to neo-adjuvant chemotherapy in children with advanced malignant peripheral nerve sheath tumor pl
dc.type JournalArticle pl
dc.description.physical 519-529 pl
dc.abstract.en Purpose Selected cell-cycle regulators and extracellular matrix proteins were found to play roles in malignant peripheral nerve sheath tumor (MPNST) biology. We aimed to analyze whether initial tumor tissue expressions of survivin, p53, cyclin D1, osteopontin (OPN) and fibronectin (FN) correlate with the response to neo-adjuvant CHT (naCHT) in children with advanced inoperable MPNST. Methods The study included 26 children with MPNST (M/F 14/12, median age 130 months) treated in Polish centers of pediatric oncology between 1992 and 2013. Tissue expression of markers was studied immunohistochemically in the manually performed tissue microarrays and assessed semi-quantitatively as low and high, based on the rate of positive cells and staining intensity. Results Good response to naCHT was noted in 47.6%, while poor-in 52.4% of patients. The response to naCHT was influenced negatively by the presence of neurofibromatosis NF1 and high initial tumor tissue expression of OPN, survivin, p53 and cyclin D1. Patients with high tumor expression of either OPN, survivin or p53 and those with simultaneous high expression of ≥ 3 of the markers, responded significantly worse to naCHT, than patients, in whom expression of ≤ 2 markers were detected at diagnosis. Nearly, 85% of patients expressing ≥ 3 markers, responded poor to CHT; while 87.5% of children, expressing ≤ 2 markers, were good responders. Conclusion The initial tumor tissue expression of OPN, survivin, p53 and cyclin D1 may serve as markers to predict response to naCHT in pediatric advanced MPNST. Future studies in more numerous group of patients are needed to confirm these preliminary results. pl
dc.subject.en survivin pl
dc.subject.en p53 pl
dc.subject.en cyclin D1 pl
dc.subject.en osteopontin pl
dc.subject.en response to neo-adjuvant chemotherapy pl
dc.subject.en malignant peripheral nerve sheath tumor pl
dc.subject.en children pl
dc.description.volume 144 pl
dc.description.number 3 pl
dc.description.points 25 pl
dc.identifier.doi 10.1007/s00432-018-2580-1 pl
dc.identifier.eissn 1432-1335 pl
dc.title.journal Journal of Cancer Research and Clinical Oncology pl
dc.affiliation Wydział Lekarski : Instytut Pediatrii pl
dc.subtype Article pl
dc.rights.original CC-BY; inne; ostateczna wersja wydawcy; w momencie opublikowania; 0 pl
dc.identifier.project ROD UJ / OP pl
dc.tmp.cm 87178
.pointsMNiSW [2018 A]: 25


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Udzielam licencji. Uznanie autorstwa 4.0 Międzynarodowa Except where otherwise noted, this item's license is described as Udzielam licencji. Uznanie autorstwa 4.0 Międzynarodowa