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Serum levels of Visfatin, Omentin and Irisin in patients with end stage lung disease before and after lung transplantation

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Serum levels of Visfatin, Omentin and Irisin in patients with end stage lung disease before and after lung transplantation

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dc.contributor.author Ochman, Marek pl
dc.contributor.author Maruszewski, Marcin pl
dc.contributor.author Wojarski, Jacek pl
dc.contributor.author Żegleń, Sławomir pl
dc.contributor.author Karolak, Wojtek pl
dc.contributor.author Stanjek-Cichoracka, Anita pl
dc.contributor.author Przybyłowski, Piotr [SAP20001438] pl
dc.contributor.author Zembala, Marian pl
dc.contributor.author Kukla, Michał pl
dc.date.accessioned 2020-01-17T09:20:24Z
dc.date.available 2020-01-17T09:20:24Z
dc.date.issued 2017 pl
dc.identifier.issn 1425-9524 pl
dc.identifier.uri https://ruj.uj.edu.pl/xmlui/handle/item/142273
dc.language eng pl
dc.rights Udzielam licencji. Uznanie autorstwa - Użycie niekomercyjne - Bez utworów zależnych 4.0 Międzynarodowa *
dc.rights.uri http://creativecommons.org/licenses/by-nc-nd/4.0/pl/legalcode *
dc.title Serum levels of Visfatin, Omentin and Irisin in patients with end stage lung disease before and after lung transplantation pl
dc.type JournalArticle pl
dc.description.physical 765-772 pl
dc.abstract.en BACKGROUND: The aim of this study was to investigate serum concentrations of visfatin, irisin, and omentin in patients with end-stage lung diseases (ESLD) before and after lung transplantation (LTx) and to find relationship between adipokines levels and clinical outcomes. MATERIAL AND METHODS: Fourteen consecutive lung transplant recipients (six males and seven females; age 32.0±14.2 years; body mass index (BMI) 21.8±5.3 kg/m²) who underwent lung transplantation with initial diagnosis of respiratory failure due to cystic fibrosis (CF), chronic obstructive pulmonary disease (COPD), idiopathic pulmonary fibrosis (IPF) were included. Visfatin, irisin, and omentin serum levels were assayed using commercially available ELISA kits at four time points: the day of LTx (day 0), 72 hours (day 3), one month (day 30) and three months (day 90) after LTx. RESULTS: Omentin serum concentration decreased significantly within three days after LTx (350.5±302.0 to 200.0±0.90 ng/mL; p<0.05), while visfatin serum levels decreased later, 30 days after Ltx (4.81±3.78 to 0.78±0.35 [0.4–1.1] pg/mL; p<0.05). Downregulated serum levels of both adipokines remained stable for the next two months (256.0 [201.7–642.9] ng/mL and 0.77±0.76 pg/mL, respectively; p<0.05). Serum levels of irisin were unchanged before and after Ltx. Immunosuppressive regimen did not affect serum levels of the analyzed adipokines. CONCLUSIONS: The study showed for the first time serum omentin and visfatin levels to be decreased after LTx in ESLD patients. Successful LTx contributes to the improvement of impaired lung function parameters and attenuation of ongoing inflammatory process, resulting in altered visfatin and omentin serum levels. Additional influence of immunosuppressive treatment on omentin and visfatin serum concentration cannot be excluded. pl
dc.subject.en adipokines pl
dc.subject.en immunosuppressive agents pl
dc.subject.en lung transplantation pl
dc.description.volume 22 pl
dc.description.points 20 pl
dc.identifier.doi 10.12659/AOT.904994 pl
dc.identifier.eissn 2329-0358 pl
dc.title.journal Annals of Transplantation pl
dc.affiliation Wydział Lekarski : Klinika Chirurgii Ogólnej, Onkologicznej i Gastroenterologicznej pl
dc.subtype Article pl
dc.rights.original CC-BY-NC-ND; otwarte czasopismo; ostateczna wersja wydawcy; w momencie opublikowania; 0 pl
dc.identifier.project ROD UJ / OP pl
dc.tmp.cm 86973
.pointsMNiSW [2017 A]: 20


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Udzielam licencji. Uznanie autorstwa - Użycie niekomercyjne - Bez utworów zależnych 4.0 Międzynarodowa Except where otherwise noted, this item's license is described as Udzielam licencji. Uznanie autorstwa - Użycie niekomercyjne - Bez utworów zależnych 4.0 Międzynarodowa