Jagiellonian University Repository
Serum levels of Visfatin, Omentin and Irisin in patients with end stage lung disease before and after lung transplantation
Communities & Collections
pcg.skipToMenu
Except where otherwise noted, this item's license is described as Udzielam licencji. Uznanie autorstwa - Użycie niekomercyjne - Bez utworów zależnych 4.0 Międzynarodowa
Serum levels of Visfatin, Omentin and Irisin in patients with end stage lung disease before and after lung transplantation
Bibliographic description
| title: | Serum levels of Visfatin, Omentin and Irisin in patients with end stage lung disease before and after lung transplantation |
| author: | Ochman Marek, Maruszewski Marcin, Wojarski Jacek, Żegleń Sławomir, Karolak Wojtek, Stanjek-Cichoracka Anita, Przybyłowski Piotr  , Zembala Marian, Kukla Michał |
| journal title: | Annals of Transplantation |
| volume: | 22 |
| date of publication : | 2017 |
| pages: | 765-772 |
| ISSN: |
1425-9524 |
| eISSN: |
2329-0358 |
| DOI: | |
| language: | English |
| journal language: | English |
| abstract in English: | BACKGROUND: The aim of this study was to investigate serum concentrations of visfatin, irisin, and omentin in patients with end-stage lung diseases (ESLD) before and after lung transplantation (LTx) and to find relationship between adipokines levels and clinical outcomes. MATERIAL AND METHODS: Fourteen consecutive lung transplant recipients (six males and seven females; age 32.0±14.2 years; body mass index (BMI) 21.8±5.3 kg/m²) who underwent lung transplantation with initial diagnosis of respiratory failure due to cystic fibrosis (CF), chronic obstructive pulmonary disease (COPD), idiopathic pulmonary fibrosis (IPF) were included. Visfatin, irisin, and omentin serum levels were assayed using commercially available ELISA kits at four time points: the day of LTx (day 0), 72 hours (day 3), one month (day 30) and three months (day 90) after LTx. RESULTS: Omentin serum concentration decreased significantly within three days after LTx (350.5±302.0 to 200.0±0.90 ng/mL; p<0.05), while visfatin serum levels decreased later, 30 days after Ltx (4.81±3.78 to 0.78±0.35 [0.4–1.1] pg/mL; p<0.05). Downregulated serum levels of both adipokines remained stable for the next two months (256.0 [201.7–642.9] ng/mL and 0.77±0.76 pg/mL, respectively; p<0.05). Serum levels of irisin were unchanged before and after Ltx. Immunosuppressive regimen did not affect serum levels of the analyzed adipokines. CONCLUSIONS: The study showed for the first time serum omentin and visfatin levels to be decreased after LTx in ESLD patients. Successful LTx contributes to the improvement of impaired lung function parameters and attenuation of ongoing inflammatory process, resulting in altered visfatin and omentin serum levels. Additional influence of immunosuppressive treatment on omentin and visfatin serum concentration cannot be excluded. |
| keywords in English: | adipokines, immunosuppressive agents, lung transplantation |
| departmental parameterization: | 20 |
| affiliation: | Wydział Lekarski : Klinika Chirurgii Ogólnej, Onkologicznej i Gastroenterologicznej |
| type: | journal article |
| subtype: | academic paper |
Files in this item
This item appears in the following Collection(s)
Except where otherwise noted, this item's license is described as Udzielam licencji. Uznanie autorstwa - Użycie niekomercyjne - Bez utworów zależnych 4.0 Międzynarodowa
Projekt „Repozytorium otwartego dostępu do dorobku naukowego i dydaktycznego UJ” współfinansowany w ramach poddziałania 2.3.1 „Cyfrowe udostępnianie zasobów nauki” Programu Operacyjnego Polska Cyfrowa z Europejskiego Funduszu Rozwoju Regionalnego i budżetu państwa na podstawie umowy o dofinansowanie nr POPC.02.03.01-00-0030/17-00
