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In silico assessment of antiarrhythmic effects of drug ranolazine on electrical activity in human ventricular myocardium

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In silico assessment of antiarrhythmic effects of drug ranolazine on electrical activity in human ventricular myocardium

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dc.contributor.author Abbasi, Mitra pl
dc.contributor.author Polak, Sebastian [SAP20002046] pl
dc.date.accessioned 2020-01-17T09:16:29Z
dc.date.available 2020-01-17T09:16:29Z
dc.date.issued 2016 pl
dc.identifier.issn 2325-8861 pl
dc.identifier.uri https://ruj.uj.edu.pl/xmlui/handle/item/140592
dc.language eng pl
dc.rights Udzielam licencji. Uznanie autorstwa 4.0 Międzynarodowa *
dc.rights.uri http://creativecommons.org/licenses/by/4.0/pl/legalcode *
dc.title In silico assessment of antiarrhythmic effects of drug ranolazine on electrical activity in human ventricular myocardium pl
dc.type JournalArticle pl
dc.abstract.en The aim of this study was to simulate the electrophysiological modifications by the ranolazine at the left ventricular wall level by using in vitro electrophysiological measurements from canine ventricular myocytes to generate early information on cardiac safety in the human heart. The antiarrhythmic effect of ranolazine on two proarrhythmic drugs was examined. The sensitivity of ionic currents to ranolazine was described as Action Potential Duration (APD) variations in response to different therapeutic concentrations. The observed results can be explained by the interplay between inhibition of the INaL and IKr currents. Simulation results are in agreement with in vitro and in vivo studies of arrhythmia and confirmed the antiarrhythmic properties of ranolazine which may be utilized for suppressing ventricular arrhythmias. pl
dc.description.volume 43 pl
dc.description.points 5 pl
dc.description.publication 0,5 pl
dc.identifier.doi 10.22489/CinC.2016.309-284 pl
dc.identifier.eissn 2325-887X
dc.title.journal Computing in Cardiology pl
dc.language.container eng pl
dc.affiliation Wydział Farmaceutyczny : Zakład Farmacji Społecznej pl
dc.subtype Article pl
dc.identifier.articleid 7868932 pl
dc.rights.original CC-BY; otwarte czasopismo; ostateczna wersja wydawcy; w momencie opublikowania; 0 pl
dc.identifier.project ROD UJ / OP pl
dc.cm.id 82220
dc.cm.date 2020-01-07


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Udzielam licencji. Uznanie autorstwa 4.0 Międzynarodowa Except where otherwise noted, this item's license is described as Udzielam licencji. Uznanie autorstwa 4.0 Międzynarodowa