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Evaluation of anti-inflammatory and ulcerogenic potential of zinc-ibuprofen and zinc-naproxen complexes in rats

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Evaluation of anti-inflammatory and ulcerogenic potential of zinc-ibuprofen and zinc-naproxen complexes in rats

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dc.contributor.author Gaweł, Magdalena pl
dc.contributor.author Szkaradek, Natalia [SAP20002583] pl
dc.contributor.author Marona, Henryk [SAP20000903] pl
dc.contributor.author Nowak, Gabriel [SAP20001917] pl
dc.contributor.author Młyniec, Katarzyna [SAP20013564] pl
dc.contributor.author Librowski, Tadeusz [SAP20001628] pl
dc.date.accessioned 2020-01-17T09:16:28Z
dc.date.available 2020-01-17T09:16:28Z
dc.date.issued 2017 pl
dc.identifier.issn 0925-4692 pl
dc.identifier.uri https://ruj.uj.edu.pl/xmlui/handle/item/140566
dc.language eng pl
dc.rights Udzielam licencji. Uznanie autorstwa 4.0 Międzynarodowa *
dc.rights.uri http://creativecommons.org/licenses/by/4.0/pl/legalcode *
dc.title Evaluation of anti-inflammatory and ulcerogenic potential of zinc-ibuprofen and zinc-naproxen complexes in rats pl
dc.type JournalArticle pl
dc.description.physical 653-663 pl
dc.description.additional Magdalena Gaweł podpisana: Magdalena Jarosz pl
dc.abstract.en Because of numerous indications and high availability, non-steroidal anti-inflammatory drugs (NSAIDs) are among the most commonly prescribed and used medicines in the world. However, long-term therapy with and improper use of NSAIDs may lead to gastrointestinal damage. Therefore, improving the therapeutic index of the existing drugs has become a priority over the past decades. Considerable attention in the field has been concentrated on metal complexes of non-steroidal anti-inflammatory drugs. The aim of this study is to evaluate the effect of complexation with zinc on the anti-inflammatory and ulcerogenic effects of ibuprofen and naproxen after single and triple intragastric administration to rats. The anti-inflammatory effect was assessed in carrageenan-induced inflammatory edema in the hind paw of male albino Wistar rats. The mucosal lesions were inspected and evaluated for gross pathology. Single administration of both the investigated complexes, namely zinc-ibuprofen and zinc-naproxen (20 mg/kg equivalent to ibuprofen and naproxen, respectively) and their parent drugs and physical mixtures with zinc hydroaspartate (ZHA doses: 16.05 and 14.37 mg/kg), caused a significant reduction of the edema after the same time from the carrageenan injection in comparison to the control groups. However, no statistically significant differences between the investigated drugs were observed after their single administration. The mean ulceration score for the mixture of ibuprofen and ZHA was statistically lower than the mean score achieved in rats after treatment with ibuprofen alone. On the other hand, triple intragastric administration of the ZHA-ibuprofen and ZHA- naproxen combination showed substantial enhancement of the anti-inflammatory activity against control groups, as well as against the parent NSAIDs. The most potent anti-inflammatory activity was demonstrated after 2 h from the carrageenan injection in animals receiving ZHA together with naproxen. The edema growth was reduced in these animals by 80.9% as compared to the control group. This result was significantly higher than the results achieved in animals receiving zinc-naproxen (50.2%) or naproxen alone (47.9%). Both NSAID complexes with zinc and mixtures with ZHA alleviated ulcerations caused by parent NSAIDs; however, the mixtures of both ibuprofen and naproxen with ZHA after triple administration were the least damaging. In view of the above results, zinc supplementation during NSAID therapy may have a beneficial effect on ulcer prevention and healing by reducing the effective dose of the parent drug and increasing its potency. pl
dc.subject.en zinc pl
dc.subject.en NSAIDs pl
dc.subject.en zinc complexes pl
dc.subject.en anti-inflammatory activity pl
dc.subject.en gastric ulcers pl
dc.description.volume 25 pl
dc.description.number 6 pl
dc.description.points 25 pl
dc.identifier.doi 10.1007/s10787-017-0361-0 pl
dc.identifier.eissn 1568-5608 pl
dc.title.journal Inflammopharmacology pl
dc.language.container eng pl
dc.affiliation Wydział Farmaceutyczny : Zakład Chemii Bioorganicznej pl
dc.affiliation Wydział Farmaceutyczny : Zakład Cytobiologii pl
dc.affiliation Wydział Farmaceutyczny : Zakład Radioligandów pl
dc.subtype Article pl
dc.rights.original CC-BY; inne; ostateczna wersja wydawcy; w momencie opublikowania; 0 pl
dc.identifier.project ROD UJ / OP pl
dc.cm.id 82167
dc.cm.date 2020-01-07
.pointsMNiSW [2017 A]: 25


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Udzielam licencji. Uznanie autorstwa 4.0 Międzynarodowa Except where otherwise noted, this item's license is described as Udzielam licencji. Uznanie autorstwa 4.0 Międzynarodowa