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Stężenie miedzi w surowicy w chorobie afektywnej dwubiegunowej


Stężenie miedzi w surowicy w chorobie afektywnej dwubiegunowej

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dc.contributor.author Siwek, Marcin [SAP20010629] pl
dc.contributor.author Styczeń, Krzysztof [SAP20014136] pl
dc.contributor.author Sowa-Kućma, Magdalena pl
dc.contributor.author Dudek, Dominika [SAP20001542] pl
dc.contributor.author Reczyński, Witold pl
dc.contributor.author Szewczyk, Bernadeta pl
dc.contributor.author Misztak, Paulina [SAP20017670] pl
dc.contributor.author Opoka, Włodzimierz [SAP20000419] pl
dc.contributor.author Topór-Mądry, Roman [SAP20001805] pl
dc.contributor.author Nowak, Gabriel [SAP20001917] pl
dc.contributor.author Rybakowski, Janusz K. pl
dc.date.accessioned 2020-01-17T09:14:13Z
dc.date.available 2020-01-17T09:14:13Z
dc.date.issued 2017 pl
dc.identifier.issn 0033-2674 pl
dc.identifier.uri https://ruj.uj.edu.pl/xmlui/handle/item/139551
dc.language pol pl
dc.rights Udzielam licencji. Uznanie autorstwa *
dc.rights.uri http://creativecommons.org/licenses *
dc.title Stężenie miedzi w surowicy w chorobie afektywnej dwubiegunowej pl
dc.title.alternative The serum concentration of copper in bipolar disorder pl
dc.type JournalArticle pl
dc.description.physical 469-481 pl
dc.abstract.en Aim. Some scientific reports indicate the changes in the concentration of serum copper in patients with bipolar disorder (BD), however the data are inconclusive. The aim of this study was to assess the concentration of copper in the blood serum of patients in various phases of BD compared to healthy volunteers, taking into consideration the specific clinical features, and the stage of illness. Methods. The study enrolled 133 patients with a diagnosis of BD (type I, II and NOS), including 61 people in depressive episode, 23 in mania or hypomania and 49 in remission. The control group consisted of 50 people. Atomic absorption spectrometry was used to measure the concentration of copper. Results. There were no statistically significant differences in the serum copper concentration between patients in various phases of BD (mania/hypomania, depression, remission), sub-types (Type I, Type II + NOS) or stages and healthy volunteers. However, serum copper concentrations in patients in stage 1 was significantly higher than in advanced stages (2+3+4), (β = 0.22; p = 0.02). Serum copper concentration was also the higher, the later the age of onset was (β = 0.33; p < 0.001), and the lower, the greater the number of illness episodes (β = – 0.23; p = 0.02) (multiple regression model, adj R2 = 0.19, p = 0.0001). Conclusions. The dependencies demonstrated above may reflect pathophysiological processes that occur in the course of BD (e.g., inflammatory response and oxidative stress) with a different intensity depending on its stage. pl
dc.subject.pl choroba afektywna dwubiegunowa pl
dc.subject.pl biomarkery pl
dc.subject.pl miedź pl
dc.subject.en bipolar disorder pl
dc.subject.en biomarkers pl
dc.subject.en copper pl
dc.description.volume 51 pl
dc.description.number 3 pl
dc.description.points 15 pl
dc.identifier.doi 10.12740/PP/OnlineFirst/65250 pl
dc.identifier.eissn 2391-5854 pl
dc.title.journal Psychiatria Polska pl
dc.language.container pol pl
dc.affiliation Wydział Farmaceutyczny : Katedra Farmakobiologii pl
dc.affiliation Wydział Farmaceutyczny : Zakład Chemii Nieorganicznej pl
dc.affiliation Wydział Farmaceutyczny : Zakład Cytobiologii pl
dc.affiliation Wydział Lekarski : Zakład Zaburzeń Afektywnych pl
dc.affiliation Wydział Lekarski : Klinika Psychiatrii Dorosłych pl
dc.affiliation Wydział Nauk o Zdrowiu : Instytut Zdrowia Publicznego pl
dc.subtype Article pl
dc.rights.original CC-BY; otwarte czasopismo; ostateczna wersja wydawcy; w momencie opublikowania; 0 pl
dc.identifier.project ROD UJ / OP pl
dc.cm.id 80350
dc.cm.date 2020-01-07
.pointsMNiSW [2017 A]: 15

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Udzielam licencji. Uznanie autorstwa Except where otherwise noted, this item's license is described as Udzielam licencji. Uznanie autorstwa