autor: |
Raźny Urszula , Fedak Danuta , Kieć-Wilk Beata , Góralska Joanna , Gruca Anna , Zdzienicka Anna , Kieć-Klimczak Małgorzata , Solnica Bogdan , Hubalewska-Dydejczyk Alicja , Malczewska-Malec Małgorzata
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abstrakt w j. angielskim: |
Background Carboxylated osteocalcin (Gla‐OC) participates in bone remodeling, whereas the
undercarboxylated form (Glu‐OC) takes part in energy metabolism. This study was undertaken to
compare the blood levels of Glu‐OC and Gla‐OC in nonobese, healthy obese, and prediabetic
volunteers and correlate it with the metabolic markers of insulin resistance and early markers
of inflammation.
Methods Nonobese (body mass index [BMI] <30 kg/m2
; n = 34) and obese subjects (30 <BMI
<40 kg/m2
; n = 98), both sexes, aged 25 to 65 years, were divided into healthy control, normal
weight subjects, healthy obese, and obese with biochemical markers of prediabetes. The subgroups with obesity and low or high Gla‐OC or Glu‐OC were also considered for statistical
analysis. After 2 weeks of diet standardization, venous blood was sampled for the determination
of Gla‐OC, Glu‐OC, lipid profile, parameters of inflammation (hsCRP, interleukin 6, sE‐selectin,
sPECAM‐1, and monocyte chemoattractant protein 1), and adipokines (leptin, adiponectin,
visfatin, and resistin).
Results Gla‐OC in obese patients was significantly lower compared to nonobese ones
(11.36 ± 0.39 vs 12.69 ± 0.90 ng/mL, P = .048) and weakly correlated with hsCRP (r = −0.18,
P = .042), visfatin concentration (r = −0.19, P = .033), and BMI (r = −0.17, P = .047). Glu‐OC
was negatively associated with fasting insulin levels (r = −0.18, P = .049) and reduced in prediabetic individuals compared with healthy obese volunteers (3.04 ± 0.28 vs 4.48 ± 0.57, P = .025).
Conclusions Decreased blood concentration of Glu‐OC may be a selective early symptom of
insulin resistance in obesity, whereas the decreased level of Gla‐OC seems to be associated with
the appearance of early markers of low grade inflammation accompanying obesity. |
wydział: instytut / zakład / katedra: |
Wydział Lekarski : Zakład Biochemii Klinicznej, Wydział Lekarski : Zakład Diagnostyki, Wydział Lekarski : Klinika Chorób Metabolicznych, Wydział Lekarski : Zakład Diagnostyki Genetycznej i Nutrigenomiki, Wydział Lekarski : Klinika Endokrynologii |