Activated factor IX, factor XI and tissue factor identify patients with permanent atrial fibrillation treated with warfarin who are at risk of ischemic stroke
Activated factor IX, factor XI and tissue factor identify patients with permanent atrial fibrillation treated with warfarin who are at risk of ischemic stroke
Activated factor IX, factor XI and tissue factor identify patients with permanent atrial fibrillation treated with warfarin who are at risk of ischemic stroke
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dc.type
JournalArticle
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dc.description.physical
1000-1007
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dc.abstract.en
Introduction: Previously, we have demonstrated that significant proportions
of patients with various cardiovascular diseases have active tissue factor
and active factor XIa in their plasma. In the current study, we evaluated
active tissue factor and active factors (F)XI and FIX in plasma from patients
with atrial fibrillation.
Material and methods: In 110 consecutive patients with permanent atrial
fibrillation receiving warfarin, we determined active tissue factor, together
with plasma FIXa and FXIa, using clotting assays by measuring the response
to inhibitory monoclonal antibodies.
Results: Sixteen (14.5%) patients had detectable active tissue factor and active FXIa, including 11 subjects with both factors, while FIXa was observed in
28 (25.7%) patients. The three positive groups did not differ from the patients
without these factors with regard to demographic and clinical characteristics.
Von Willebrand factor was higher in the active tissue factor-positive group
(p < 0.0001) and FXIa-positive group (p = 0.0037). Individuals positive for active tissue factor and FXIa had higher plasma interleukin-6 levels (p = 0.0014
and 0.0322, respectively). The presence of active tissue factor, FXIa and FIXa
in anticoagulated patients with permanent atrial fibrillation correlated with
elevated von Willebrand factor and interleukin-6. During a 3-year follow-up,
ischemic stroke (n = 12, 10.9%) occurred more commonly among atrial fibrillation patients who had circulating TF (p = 0.002) or FXIa (p = 0.013).
Conclusions: These data suggest that circulating active coagulation factors,
in particular TF and FXIa, can be detected despite oral anticoagulation in
a significant proportion of patients with atrial fibrillation, and could represent novel markers of persistent prothrombotic alterations predisposing to
ischemic stroke.
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dc.subject.en
anticoagulation
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dc.subject.en
arrhythmia
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dc.subject.en
blood coagulation
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dc.subject.en
stroke
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dc.description.volume
12
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dc.description.number
5
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dc.description.points
30
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dc.identifier.doi
10.5114/aoms.2015.54791
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dc.identifier.eissn
1896-9151
dc.title.journal
Archives of Medical Science
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dc.language.container
eng
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dc.affiliation
Wydział Lekarski : Instytut Kardiologii
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dc.subtype
Article
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dc.rights.original
CC-BY-NC-SA; otwarte czasopismo; ostateczna wersja wydawcy; w momencie opublikowania; 0
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