Introduction: The skin prick test is still the first and basic procedure in the diagnosis of allergic diseases. The possibility
of using a sensitive thermographic method supported by the mathematical model for the assessment of
skin test results will be highlighted in the studies.
Aim: To compare the proposed approach with routine planimetric and thermographic methods.
Material and methods: A mathematical model of allergic reaction was developed. Simplifying assumptions of the
IgE-mediated skin reaction is the essence of the model. Investigations were performed in a group of 40 patients.
Results: Using the spatio-temporal evolution of temperature distributions, the ratios of the histamine released from
mast cells to the control histamine were determined. The obtained values very well correlate with the standard
evaluation of skin prick tests (correlation coefficient = 0.98).
Conclusions: The proposed method of skin test evaluation presents several advantages. The continuous acquisition
of data provides the monitoring of time course of the allergic response. The transport of mediator and its concentration
were distinctly discriminated, which may be diagnostically useful, especially for abnormal cases. The high
sensitivity of the method enables studying patients regardless of age and skin sensitivity.
keywords in English:
skin prick tests, thermography, mathematical model
departmental parameterization:
15
affiliation:
Wydział Lekarski : Zakład Biofizyki, Wydział Lekarski : Klinika Chorób Wewnętrznych i Medycyny Wsi
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