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Effect of caloric restriction with or without n-3 polyunsaturated fatty acids on insulin sensitivity in obese subjects : a randomized placebo controlled trial

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Effect of caloric restriction with or without n-3 polyunsaturated fatty acids on insulin sensitivity in obese subjects : a randomized placebo controlled trial

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dc.contributor.author Raźny, Urszula [SAP20008392] pl
dc.contributor.author Kieć-Wilk, Beata [SAP20002402] pl
dc.contributor.author Polus, Anna [SAP20007371] pl
dc.contributor.author Góralska, Joanna [SAP20008528] pl
dc.contributor.author Malczewska-Malec, Małgorzata [SAP20001948] pl
dc.contributor.author Wnek, Dominika pl
dc.contributor.author Zdzienicka, Anna [SAP20006468] pl
dc.contributor.author Gruca, Anna [SAP20007470] pl
dc.contributor.author Childs, Caroline E. pl
dc.contributor.author Kapusta, Maria [SAP20002304] pl
dc.contributor.author Słowińska-Solnica, Krystyna [SAP20006966] pl
dc.contributor.author Calder, Philip C. pl
dc.contributor.author Dembińska-Kieć, Aldona [SAP20000764] pl
dc.date.accessioned 2020-01-17T09:04:05Z
dc.date.available 2020-01-17T09:04:05Z
dc.date.issued 2015 pl
dc.identifier.uri https://ruj.uj.edu.pl/xmlui/handle/item/137884
dc.language eng pl
dc.rights Udzielam licencji. Uznanie autorstwa - Użycie niekomercyjne - Bez utworów zależnych 4.0 Międzynarodowa *
dc.rights.uri http://creativecommons.org/licenses/by-nc-nd/4.0/pl/legalcode *
dc.title Effect of caloric restriction with or without n-3 polyunsaturated fatty acids on insulin sensitivity in obese subjects : a randomized placebo controlled trial pl
dc.type JournalArticle pl
dc.description.physical 7-13 pl
dc.abstract.en Background: Caloric restriction and n-3 polyunsaturated fatty acid (PUFA) supplementation protect fromsome of themetabolic complications. The aim of this study was to assess the influence of a low calorie diet with or without n-3 PUFA supplementation on glucose dependent insulinotropic polypeptide (GIP) output and insulin sensitivity markers in obese subjects. Methods: Obese, non-diabetic subjects (BMI $30-40 kg/m^{2}$) and aged 25-65 yr. were put on low calorie diet (1200-1500 kcal/day) supplemented with either 1.8 g/day n-3 PUFA (DHA/EPA, 5:1) (n=24) or placebo capsules (n= 24) for three months in a randomized placebo controlled trial. Insulin resistance markers and GIP levels were analysed from samples obtained at fasting and during an oral glucose tolerance test (OGTT). Results: Caloric restriction with n-3 PUFA led to a decrease of insulin resistance index (HOMA-IR) and a significant reduction of insulin output as well as decreased GIP secretion during the OGTT. These effects were not seen with caloric restriction alone. Changes in GIP output were inversely associatedwith changes in red blood cell EPA content whereas fasting GIP level positively correlatedwith HOMA-IR index. Blood triglyceride levelwas lowered by caloric restriction with a greater effect when n-3 PUFA were included and correlated positively with fasting GIP level. Conclusions: Three months of caloric restriction with DHA + EPA supplementation exerts beneficial effects on insulin resistance, GIP and triglycerides. General significance: Combining caloric restriction and n-3 PUFA improves insulin sensitivity, whichmay be related to a decrease of GIP levels. pl
dc.subject.en n-3 polyunsaturated fatty acids pl
dc.subject.en docosahexaenoic acid pl
dc.subject.en eicosapentaenoic acid pl
dc.subject.en caloric restriction pl
dc.subject.en insulin resistance pl
dc.subject.en obesity pl
dc.description.volume 4 pl
dc.description.points 5 pl
dc.description.publication 1,24 pl
dc.identifier.doi 10.1016/j.bbacli.2015.05.001 pl
dc.identifier.eissn 2214-6474
dc.title.journal BBA Clinical pl
dc.affiliation Wydział Lekarski : Zakład Biochemii Klinicznej pl
dc.affiliation Wydział Lekarski : Klinika Chorób Metabolicznych pl
dc.affiliation Wydział Lekarski : Zakład Diagnostyki Genetycznej i Nutrigenomiki pl
dc.affiliation Wydział Lekarski : Zakład Diagnostyki pl
dc.subtype Article pl
dc.rights.original CC-BY-NC-ND; otwarte czasopismo; ostateczna wersja wydawcy; w momencie opublikowania; 0 pl
dc.identifier.project ROD UJ / OP pl
dc.tmp.cm 77751


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Udzielam licencji. Uznanie autorstwa - Użycie niekomercyjne - Bez utworów zależnych 4.0 Międzynarodowa Except where otherwise noted, this item's license is described as Udzielam licencji. Uznanie autorstwa - Użycie niekomercyjne - Bez utworów zależnych 4.0 Międzynarodowa