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Pretreatment with obestatin inhibits the development of acetic acid-induced colitis in rats
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Except where otherwise noted, this item's license is described as Udzielam licencji. Uznanie autorstwa - Użycie niekomercyjne - Na tych samych warunkach 4.0 Międzynarodowa
Pretreatment with obestatin inhibits the development of acetic acid-induced colitis in rats
Bibliographic description
| title: | Pretreatment with obestatin inhibits the development of acetic acid-induced colitis in rats |
| author: | Matuszyk Aleksandra  , Ceranowicz Piotr , Warzecha Zygmunt , Cieszkowski Jakub , Gałązka Krystyna , Bonior Joanna , Jaworek Jolanta , Konturek Peter Christopher, Gil Krzysztof , Dembiński Artur
|
| journal title: | Archives of Medical Science |
| volume: | 14 |
| issue: | 4 |
| date of publication : | 2018 |
| pages: | 920-929 |
| ISSN: |
1734-1922 |
| eISSN: |
1896-9151 |
| DOI: | |
| language: | English |
| journal language: | English |
| abstract in English: | Introduction: Obestatin is a 23-amino acid peptide derived from proghrelin, a common prohormone for ghrelin and obestatin. Previous studies have shown that obestatin exhibits some protective and therapeutic effects in the pancreas and stomach. The aim of this study was to examine the effect of pretreatment with obestatin on the development of acetic acid-induced colitis. Material and methods: Studies were performed on Wistar rats. Before induction of colitis, rats were treated intraperitoneally with saline or obestatin, administered twice at a dose of 4, 8 or 16 nmol/kg/dose. The first dose of saline or obestatin was administered 8 h before the induction of colitis, the second one 7 h after the first dose. Colitis was induced by enema with 1 ml of 4% acetic acid solution. The severity of colitis was assessed 1 or 24 h after administration of enema. Results: Pretreatment with obestatin administered at a dose of 8 or 16 nmol/ kg/dose significantly reduced the area of mucosal damage evoked by enema with acetic acid (p < 0.05). This effect was accompanied by an improvement of mucosal blood flow and DNA synthesis in the colon. Moreover, obestatin administered at a dose of 8 or 16 nmol/kg/dose significantly reduced mucosal concentration of IL-1β and activity of myeloperoxidase (p < 0.05). Conclusions: Pretreatment with obestatin exhibited a protective effect in the colon, leading to a reduction of colonic damage in acetic acid-induced colitis. This effect was associated with an improvement of mucosal blood flow, an increase in mucosal cell proliferation, and a decrease in local inflammation. |
| keywords in English: | cell proliferation, blood flow, myeloperoxidase, interleukin-1β |
| departmental parameterization: | 30 |
| affiliation: | Wydział Lekarski : Zakład Anatomii, Wydział Lekarski : Zakład Fizjologii Klinicznej, Wydział Lekarski : Zakład Patomorfologii Klinicznej i Doświadczalnej, Wydział Lekarski : Zakład Patofizjologii, Wydział Nauk o Zdrowiu : Instytut Fizjoterapii |
| type: | journal article |
| subtype: | academic paper |
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Except where otherwise noted, this item's license is described as Udzielam licencji. Uznanie autorstwa - Użycie niekomercyjne - Na tych samych warunkach 4.0 Międzynarodowa
Projekt „Repozytorium otwartego dostępu do dorobku naukowego i dydaktycznego UJ” współfinansowany w ramach poddziałania 2.3.1 „Cyfrowe udostępnianie zasobów nauki” Programu Operacyjnego Polska Cyfrowa z Europejskiego Funduszu Rozwoju Regionalnego i budżetu państwa na podstawie umowy o dofinansowanie nr POPC.02.03.01-00-0030/17-00
