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Low prevalence of collateral cerebral circulation in the circle of Willis in patients with severe carotid artery stenosis and recent ischemic stroke

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Low prevalence of collateral cerebral circulation in the circle of Willis in patients with severe carotid artery stenosis and recent ischemic stroke

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dc.contributor.author Badacz, Rafał [SAP20017095] pl
dc.contributor.author Przewłocki, Tadeusz [SAP20001929] pl
dc.contributor.author Karch, Izabela pl
dc.contributor.author Odrowąż-Pieniążek, Piotr [SAP20001575] pl
dc.contributor.author Rosławiecka, Agnieszka pl
dc.contributor.author Mleczko, Szymon pl
dc.contributor.author Brzychczy, Andrzej pl
dc.contributor.author Trystuła, Mariusz [SAP20013335] pl
dc.contributor.author Żmudka, Krzysztof [SAP20001324] pl
dc.contributor.author Kabłak-Ziembicka, Anna [SAP20002416] pl
dc.date.accessioned 2020-01-17T08:59:00Z
dc.date.available 2020-01-17T08:59:00Z
dc.date.issued 2015 pl
dc.identifier.issn 1734-9338 pl
dc.identifier.uri https://ruj.uj.edu.pl/xmlui/handle/item/136647
dc.language eng pl
dc.rights Udzielam licencji. Uznanie autorstwa - Użycie niekomercyjne - Na tych samych warunkach 4.0 Międzynarodowa *
dc.rights.uri http://creativecommons.org/licenses/by-nc-sa/4.0/pl/legalcode *
dc.title Low prevalence of collateral cerebral circulation in the circle of Willis in patients with severe carotid artery stenosis and recent ischemic stroke pl
dc.type JournalArticle pl
dc.description.physical 312-317 pl
dc.abstract.en Introduction: The circle of Willis is thought to play a key role in development of collateral flow in patients with internal carotid artery stenosis (ICAS). Aim: To assess flow in the circle of Willis in patients with recent ischemic stroke (IS). Material and methods: The study included 371 patients, 102 symptomatic with severe ICAS and recent IS (within the last 3 months) (group I) and 269 asymptomatic with severe ICAS (group II). Flow in the middle (MCA), anterior (ACA) and posterior (PCA) cerebral arteries and pattern of the cross-flow through anterior (ACoA) and posterior (PCoA) communicating arteries were assessed with transcranial color-coded Doppler ultrasonography (TCCD). Results: The ACoA or PCoA was less prevalent in group I than in group II (54% vs. 78%, p < 0.001 and 20% vs. 42%, p < 0.001, respectively), resulting in lower peak-systolic velocity (PSV) in the MCA in group I vs. group II (p = 0.015). Any collateral pathway was present in 67% of patients in group I, compared to 86% in group II (p < 0.001). Both PSV and end-diastolic (EDV) flow velocity in the ACA were lower in patients with recent IS, compared to asymptomatic subjects (71 ±24 cm/s vs. 86 ±34 cm/s, p < 0.001 and 32 ±12 cm/s vs. 37 ±17 cm/s, p = 0.038, respectively). Presence of ACoA or PCoA and higher PSV in the MCA and ACA were associated with significant risk reduction of IS (RR = 0.28 (95% CI = 0.16–0.49, p < 0.001), RR = 0.28 (95% CI = 0.15–0.52, p < 0.001), RR = 0.97 (95% CI = 0.96–0.99, p < 0.001), RR = 0.99 (95% CI = 0.98–0.99, p < 0.032), respectively). However, ROC curves failed to show reliable MCA or ACA PSV cut-offs for IS risk assessment. Conclusions: The ACoA and PCoA seem to play a key role in the evaluation of IS risk in subjects with severe ICAS. pl
dc.subject.en stroke pl
dc.subject.en circle of Willis pl
dc.subject.en collateral circulation pl
dc.subject.en transcranial Doppler pl
dc.subject.en carotid artery stenosis pl
dc.description.volume 11 pl
dc.description.number 4 (42) pl
dc.description.points 15 pl
dc.identifier.doi 10.5114/pwki.2015.55602 pl
dc.identifier.eissn 1897-4295 pl
dc.title.journal Postępy w Kardiologii Interwencyjnej pl
dc.language.container eng pl
dc.affiliation Wydział Lekarski : Instytut Kardiologii pl
dc.subtype Article pl
dc.rights.original CC-BY-NC-SA; otwarte czasopismo; ostateczna wersja wydawcy; w momencie opublikowania; 0 pl
dc.identifier.project ROD UJ / OP pl
dc.cm.id 74883
dc.cm.date 2020-01-07
.pointsMNiSW [2015 A]: 15


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Udzielam licencji. Uznanie autorstwa - Użycie niekomercyjne - Na tych samych warunkach 4.0 Międzynarodowa Except where otherwise noted, this item's license is described as Udzielam licencji. Uznanie autorstwa - Użycie niekomercyjne - Na tych samych warunkach 4.0 Międzynarodowa