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Advances in studying phasic dopamine signaling in brain reward mechanisms


Advances in studying phasic dopamine signaling in brain reward mechanisms

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dc.contributor.author Wickham, Robert J. pl
dc.contributor.author Solecki, Wojciech [SAP13012096] pl
dc.contributor.author Rathbun, Liza pl
dc.contributor.author Neugebauer, Nichole M. pl
dc.contributor.author Wightman, R. Mark pl
dc.contributor.author Addy, Nii A. pl
dc.date.accessioned 2014-09-25T14:36:45Z
dc.date.available 2014-09-25T14:36:45Z
dc.date.issued 2013 pl
dc.identifier.issn 1945-0494 pl
dc.identifier.uri http://ruj.uj.edu.pl/xmlui/handle/item/1344
dc.language eng pl
dc.title Advances in studying phasic dopamine signaling in brain reward mechanisms pl
dc.type JournalArticle pl
dc.description.physical 982-999 pl
dc.identifier.weblink http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3725633/ pl
dc.abstract.en The last sixty years of research has provided extraordinary advances of our knowledge of the reward system. Since its discovery as a neurotransmitter by Carlsson and colleagues (1), dopamine (DA) has emerged as an important mediator of reward processing. As a result, a number of electrochemical techniques have been developed to measure DA in the brain. Together, these techniques have begun to elucidate the complex roles of tonic and phasic DA signaling in reward processing and addiction. In this review, we will first provide a guide for the most commonly used electrochemical methods for DA detection and describe their utility in furthering our knowledge about DA's role in reward and addiction. Second, we will review the value of common in vitro and in vivo preparations and describe their ability to address different types of questions. Last, we will review recent data that has provided new mechanistic insight of in vivo phasic DA signaling and its role in reward processing and reward-mediated behavior. pl
dc.subject.en dopamine pl
dc.subject.en voltammetry pl
dc.subject.en striatum pl
dc.subject.en reward-related behavior pl
dc.subject.en psychostimulant pl
dc.subject.en reinforcement learning pl
dc.description.number 5 pl
dc.description.publication 0,8 pl
dc.identifier.eissn 1945-0508 pl
dc.title.journal Frontiers in Bioscience pl
dc.language.container eng pl
dc.date.accession 2016-06-04 pl
dc.affiliation Wydział Zarządzania i Komunikacji Społecznej : Instytut Psychologii Stosowanej pl
dc.subtype Article pl
dc.rights.original OTHER; otwarte czasopismo; ostateczna wersja wydawcy; w momencie opublikowania; 0; pl

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