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Occurrence of autoantibodies for gastrointestinal autoimmune diseases in children with common variable immune deficiency and selected IgA deficiency

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Occurrence of autoantibodies for gastrointestinal autoimmune diseases in children with common variable immune deficiency and selected IgA deficiency

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dc.contributor.author Pituch-Noworolska, Anna [SAP20001443] pl
dc.contributor.author Błaut-Szlósarczyk, Anita pl
dc.contributor.author Zwonarz, Katarzyna [SAP20002570] pl
dc.date.accessioned 2020-01-17T08:03:18Z
dc.date.available 2020-01-17T08:03:18Z
dc.date.issued 2013 pl
dc.identifier.issn 1895-5770 pl
dc.identifier.uri https://ruj.uj.edu.pl/xmlui/handle/item/132704
dc.language eng pl
dc.rights Udzielam licencji. Uznanie autorstwa - Użycie niekomercyjne - Na tych samych warunkach 4.0 Międzynarodowa *
dc.rights.uri http://creativecommons.org/licenses/by-nc-sa/4.0/pl/legalcode *
dc.title Occurrence of autoantibodies for gastrointestinal autoimmune diseases in children with common variable immune deficiency and selected IgA deficiency pl
dc.type JournalArticle pl
dc.description.physical 370-376 pl
dc.abstract.en Introduction: Selected IgA deficiency (IgAD) and common variable immune deficiency (CVID) are humoral immunity deficiencies frequent in children. In both these types of immunodeficiency, autoimmune diseases are present in 20-30% of patients, but the disease profiles are different between adults and children. Autoimmune diseases of the gastrointestinal tract (IBD) and celiac disease are typical for children with IgAD and CVID. Diagnosis is based on clinical symptoms, histology of jejunum and antibodies often preceding the onset of disease. However, the diagnosis of IBD and celiac disease is difficult in immune deficiency patients due to weaker or absent production of antibodies, and different jejunum histology, particular in CVID patients. Aim: Detection of antibodies for autoimmune diseases in children with diagnosis of CVID and IgAD. Material and methods: The study included 43 children with CVID and 63 children with IgAD diagnosis. Antibodies typical for celiac disease (for endomysium, tissue transglutaminase and gliadin) were tested in IgA class (CVID patients), IgG class (IgAD, CVID patients) and found in 16 patients (3 - CVID, 13 - IgAD). Results: Antibodies for IBD (for Saccharomyces cerevisiae antigen - ASCA, goblet cells - Gab, neutrophil’s cytoplasm - ANCA, pancreatic cells - Pab) were noted in 17 patients (7 - CVID, 10 - IgAD). Celiac disease was diagnosed in two children with mild and unspecific clinical symptoms followed by introduction of a gluten-free diet. The remaining children with present antibodies but without clinical symptoms involving the gastrointestinal tract are under careful clinical observation with antibody assay every 6 months. Conclusions: The antibodies are produced despite impaired humoral immunity but the level might be low so the lower limit of positive results is postulated. pl
dc.subject.en autoimmunity pl
dc.subject.en common variable immune deficiency pl
dc.subject.en IgA deficiency pl
dc.subject.en immunoglobulin substitution pl
dc.subject.en children pl
dc.description.volume 8 pl
dc.description.number 6 pl
dc.description.points 15 pl
dc.identifier.doi 10.5114/pg.2013.39920 pl
dc.identifier.eissn 1897-4317
dc.title.journal Przegląd Gastroenterologiczny pl
dc.language.container eng pl
dc.affiliation Wydział Lekarski : Instytut Pediatrii pl
dc.subtype Article pl
dc.rights.original CC-BY-NC-SA; otwarte czasopismo; ostateczna wersja wydawcy; w momencie opublikowania; 0 pl
dc.identifier.project ROD UJ / OP pl
dc.cm.id 62304
dc.cm.date 2020-01-07
.pointsMNiSW [2013 A]: 15


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Udzielam licencji. Uznanie autorstwa - Użycie niekomercyjne - Na tych samych warunkach 4.0 Międzynarodowa Except where otherwise noted, this item's license is described as Udzielam licencji. Uznanie autorstwa - Użycie niekomercyjne - Na tych samych warunkach 4.0 Międzynarodowa