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Certain subphenotypes of aspirin-exacerbated respiratory disease distinguished by latent class analysis

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Certain subphenotypes of aspirin-exacerbated respiratory disease distinguished by latent class analysis

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dc.contributor.author Bochenek, Grażyna [SAP20000240] pl
dc.contributor.author Kuschill-Dziurda, Joanna pl
dc.contributor.author Szafraniec, Krystyna [SAP20006258] pl
dc.contributor.author Plutecka, Hanna [SAP20008584] pl
dc.contributor.author Szczeklik, Andrzej pl
dc.contributor.author Niżankowska-Mogilnicka, Ewa [SAP20000228] pl
dc.date.accessioned 2020-01-17T07:52:18Z
dc.date.available 2020-01-17T07:52:18Z
dc.date.issued 2014 pl
dc.identifier.issn 0091-6749 pl
dc.identifier.uri https://ruj.uj.edu.pl/xmlui/handle/item/131922
dc.language eng pl
dc.rights Udzielam licencji. Uznanie autorstwa - Użycie niekomercyjne - Bez utworów zależnych 4.0 Międzynarodowa *
dc.rights.uri http://creativecommons.org/licenses/by-nc-nd/4.0/pl/legalcode *
dc.title Certain subphenotypes of aspirin-exacerbated respiratory disease distinguished by latent class analysis pl
dc.type JournalArticle pl
dc.description.physical 98-103 pl
dc.abstract.en Background: Aspirin-exacerbated respiratory disease (AERD) is recognized as a distinct asthma phenotype. It usually has a severe course accompanied by chronic hyperplastic eosinophilic sinusitis with nasal polyps, blood eosinophilia, and increased concentrations of urinary leukotriene E4 (LTE4). More insightful analysis of individual patients shows this group to be nonhomogeneous. Objective: We sought to identify any likely subphenotypes in a cohort of patients with AERD through the application of latent class analysis (LCA). Methods: Clinical data from 201 patients with AERD (134 women) were collected from questionnaires. Standard spirometry, atopy traits, blood eosinophilia, and urinary LTE4 concentrations were evaluated. LCA was applied to identify possible AERD subphenotypes. Results: Four classes (subphenotypes) within the AERD phenotype were identified as follows: class 1, asthma with a moderate course, intensive upper airway symptoms, and blood eosinophilia (18.9% of patients); class 2, asthma with a mild course, relatively well controlled, and with low health care use (34.8% of patients); class 3, asthma with a severe course, poorly controlled, and with severe exacerbations and airway obstruction (41.3% of patients); and class 4, poorly controlled asthma with frequent and severe exacerbations in female subjects (5.0% of patients). Atopic status did not affect class membership. Patients with particularly intensive upper airway symptoms had the highest levels of blood eosinophilia and the highest concentrations of urinary LTE4. Conclusions: LCA revealed unique AERD subphenotypes, thus corroborating the heterogeneity of this population. Such discrimination might facilitate more individualized treatment in difficult-to-treat patients. pl
dc.subject.en aspirin pl
dc.subject.en aspirin-exacerbated respiratory disease pl
dc.subject.en asthma phenotype pl
dc.subject.en latent class analysis pl
dc.subject.en nonsteroidal antiinflammatory drugs pl
dc.description.volume 133 pl
dc.description.number 1 pl
dc.description.points 50 pl
dc.identifier.doi 10.1016/j.jaci.2013.07.004 pl
dc.identifier.eissn 1097-6825 pl
dc.title.journal Journal of Allergy and Clinical Immunology pl
dc.language.container eng pl
dc.affiliation Wydział Lekarski : Klinika Pulmonologii pl
dc.affiliation Wydział Lekarski : Zakład Biologii Molekularnej i Genetyki Klinicznej pl
dc.affiliation Wydział Nauk o Zdrowiu : Instytut Zdrowia Publicznego pl
dc.subtype Article pl
dc.rights.original CC-BY-NC-ND; inne; ostateczna wersja wydawcy; w momencie opublikowania; 0 pl
dc.identifier.project ROD UJ / OP pl
dc.cm.id 60000
dc.cm.date 2020-01-07
.pointsMNiSW [2014 A]: 50


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Udzielam licencji. Uznanie autorstwa - Użycie niekomercyjne - Bez utworów zależnych 4.0 Międzynarodowa Except where otherwise noted, this item's license is described as Udzielam licencji. Uznanie autorstwa - Użycie niekomercyjne - Bez utworów zależnych 4.0 Międzynarodowa