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The β-fibrinogen –455G/A gene polymorphism and the risk of ischaemic stroke in a Polish population

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The β-fibrinogen –455G/A gene polymorphism and the risk of ischaemic stroke in a Polish population

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dc.contributor.author Golenia, Aleksandra [SAP20012717] pl
dc.contributor.author Chrzanowska-Waśko, Joanna [SAP20016121] pl
dc.contributor.author Jagiełła, Jeremiasz [SAP20012855] pl
dc.contributor.author Wnuk, Marcin [SAP20012968] pl
dc.contributor.author Ferens, Antoni [SAP20012923] pl
dc.contributor.author Klimkowicz-Mrowiec, Aleksandra [SAP20011279] pl
dc.contributor.author Adamski, Mateusz [SAP14017745] pl
dc.contributor.author Ciećko-Michalska, Irena [SAP20001980] pl
dc.contributor.author Słowik, Agnieszka [SAP20000206] pl
dc.date.accessioned 2020-01-17T07:51:51Z
dc.date.available 2020-01-17T07:51:51Z
dc.date.issued 2013 pl
dc.identifier.issn 0028-3843 pl
dc.identifier.uri https://ruj.uj.edu.pl/xmlui/handle/item/131535
dc.language eng pl
dc.rights Udzielam licencji. Uznanie autorstwa - Użycie niekomercyjne - Bez utworów zależnych 4.0 Międzynarodowa *
dc.rights.uri http://creativecommons.org/licenses/by-nc-nd/4.0/pl/legalcode *
dc.title The β-fibrinogen –455G/A gene polymorphism and the risk of ischaemic stroke in a Polish population pl
dc.title.alternative Polimorfizm –455G/A genu β-fibrynogenu a ryzyko udaru niedokrwiennego w populacji polskiej pl
dc.type JournalArticle pl
dc.description.physical 152-156 pl
dc.identifier.weblink https://journals.viamedica.pl/neurologia_neurochirurgia_polska/article/view/60881 pl
dc.abstract.en Background and purpose: Ischaemic stroke is considered to be multifactorial and interactions between environmental and genetic factors play an important role. Although vascular risk factors are well known, the genetic ones are still undiscover - ed. In the present study, we assessed the significance of the β-fibrinogen –455G/A gene polymorphism and the risk of ischaemic stroke in a Polish population. Material and methods: 426 ischaemic stroke patients classified according to stroke aetiologies (small vessel disease, large vessel disease or cardioembolic stroke) and 234 controls were included in the study. The association of the β-fibrinogen genotypes with ischaemic stroke was tested using logistic regression analysis under dominant, recessive or additive models of inheritance. Results: The allele and genotype distributions of the β-fibri - nogen –455G/A gene polymorphism did not differ significantly between patients and controls (patients: G – 75%, GG – 56.6%, GA – 36.8%, AA – 6.6%; controls: G – 73.7%, GG – 57.3%, GA – 32.9%, AA – 9.8%; p > 0.05, χ2). In addition, logistic regression analysis adjusted for the known risk factors, i.e. hypertension, ischaemic heart disease, myocardial infarction, hypercholesterolaemia, diabetes mellitus and smoking, did not show a role of the studied polymorphism in ischaemic stroke. Conclusions: The β-fibrinogen –455G/A gene polymorphism is not a risk factor for ischaemic stroke in a Polish population. pl
dc.subject.pl udar niedokrwienny mózgu pl
dc.subject.pl fibrynogen pl
dc.subject.pl polimorfizm pl
dc.subject.en ischaemic stroke pl
dc.subject.en fibrinogen pl
dc.subject.en single nucleotide polymorphism pl
dc.description.volume 47 pl
dc.description.number 2 pl
dc.description.points 15 pl
dc.identifier.doi 10.5114/ninp.2013.34462 pl
dc.identifier.eissn 1897-4260 pl
dc.title.journal Neurologia i Neurochirurgia Polska pl
dc.language.container eng pl
dc.date.accession 2021-03-03 pl
dc.affiliation Wydział Lekarski : Klinika Neurologii pl
dc.affiliation Wydział Lekarski : Klinika Gastroenterologii i Hepatologii pl
dc.affiliation Wydział Lekarski : Zakład Neurogenetyki pl
dc.subtype Article pl
dc.rights.original CC BY-NC-ND; otwarte czasopismo; ostateczna wersja wydawcy; po opublikowaniu; 12 pl
dc.identifier.project ROD UJ / OP pl
dc.cm.id 58853
dc.cm.date 2020-01-07
.pointsMNiSW [2013 A]: 15


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Udzielam licencji. Uznanie autorstwa - Użycie niekomercyjne - Bez utworów zależnych 4.0 Międzynarodowa Except where otherwise noted, this item's license is described as Udzielam licencji. Uznanie autorstwa - Użycie niekomercyjne - Bez utworów zależnych 4.0 Międzynarodowa