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Genotype-dependent consequences of traumatic stress in four inbred mouse strains

Genotype-dependent consequences of traumatic stress ...

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dc.contributor.author Szklarczyk, Klaudia pl
dc.contributor.author Korostyński, Michał pl
dc.contributor.author Gołda, Sławomir [USOS58766] pl
dc.contributor.author Solecki, Wojciech [SAP13012096] pl
dc.contributor.author Przewłocki, Ryszard [SAP11017430] pl
dc.date.accessioned 2014-09-24T15:23:20Z
dc.date.available 2014-09-24T15:23:20Z
dc.date.issued 2012 pl
dc.identifier.issn 1601-1848 pl
dc.identifier.uri http://ruj.uj.edu.pl/xmlui/handle/item/1263
dc.language eng pl
dc.title Genotype-dependent consequences of traumatic stress in four inbred mouse strains pl
dc.type JournalArticle pl
dc.description.physical 977-985 pl
dc.abstract.en Post-traumatic stress disorder (PTSD) is an anxiety disorder that develops in predisposed individuals following a terrifying event. Studies on isogenic animal populations might explain susceptibility to PTSD by revealing associations between the molecular and behavioural consequences of traumatic stress. Our study employed four inbred mouse strains to search for differences in post-stress response to a 1.5-mA electric foot shock. One day to 6 weeks after the foot shock anxiety, depression and addiction-like phenotypes were assessed. In addition, expression levels of selected stress-related genes were analysed in hippocampus and amygdala. C57BL/6J mice exhibited up-regulation in the expression of Tsc22d3, Nfkbia, Plat and Crhr1 genes in both brain regions. These alterations were associated with an increase of sensitized fear and depressive-like behaviour over time. Traumatic stress induced expression of Tsc22d3, Nfkbia, Plat and Fkbp5 genes and developed social withdrawal in DBA/2J mice. In 129P3/J strain, exposure to stress produced the up-regulation of Tsc22d3 and Nfkbia genes and enhanced sensitivity to the rewarding properties of morphine. Whereas, SWR/J mice displayed increase only in Pdyn expression in the amygdala and had the lowest conditioned fear. Our results reveal a complex genetic background of phenotypic variation in response to stress and indicate the SWR/J strain as a valuable model of stress resistance. We found potential links between the alterations in expression of Tsc22d3, Nfkbia and Pdyn, and different aspects of susceptibility to stress. pl
dc.subject.en Amygdala pl
dc.subject.en fear pl
dc.subject.en hippocampus pl
dc.subject.en inbred strains pl
dc.subject.en mouse models pl
dc.subject.en Nfkbia pl
dc.subject.en post-traumatic stress disorder pl
dc.subject.en prodynorphin pl
dc.subject.en stress-responsive genes pl
dc.subject.en Tsc22d3 pl
dc.description.volume 11 pl
dc.description.number 8 pl
dc.identifier.doi 10.1111/j.1601-183X.2012.00850.x pl
dc.identifier.eissn 1601-183X pl
dc.title.journal Genes, Brain and Behavior pl
dc.language.container eng pl
dc.affiliation Wydział Zarządzania i Komunikacji Społecznej : Instytut Psychologii Stosowanej pl
dc.subtype Article pl
dc.rights.original OTHER; inne; ostateczna wersja wydawcy; w momencie opublikowania; 0; pl
.pointsMNiSW [2012 A]: 35


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