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Role of Mc1r in UV-induced melanoma in animal models

Role of Mc1r in UV-induced melanoma in animal models

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dc.contributor.author Wolnicka-Głubisz, Agnieszka [SAP11017905] pl
dc.date.accessioned 2015-07-06T08:23:13Z
dc.date.available 2015-07-06T08:23:13Z
dc.date.issued 2014 pl
dc.identifier.issn 2157-2518 pl
dc.identifier.uri http://ruj.uj.edu.pl/xmlui/handle/item/11594
dc.language eng pl
dc.rights Udzielam licencji. Uznanie autorstwa *
dc.rights.uri https://creativecommons.org/licenses *
dc.title Role of Mc1r in UV-induced melanoma in animal models pl
dc.type JournalArticle pl
dc.abstract.en The role of UV and pigmentation are very difficult to control for in human studies, and mechanisms difficult to infer based on statistical association with melanoma. The animal models are not representative of the human situation. But on the other hand, animal studies can be useful for basic studies that will ultimately help in building up a picture of the overall network of in vivo cellular behavior and intra and inter cellular pathways contributing to melanoma progression and the effects (or not) of UV radiation in individuals with MC1R variants. This review describes that, although the Mc1r is a determinant of coat color phenotype as the MC1R is a determinant of hair and skin color in humans, deficiency of the Mc1r in mice is associated with a paradoxical lower incidence of melanoma. pl
dc.subject.en Mc1r pl
dc.subject.en melanoma pl
dc.subject.en UV pl
dc.subject.en HGF pl
dc.subject.en c-Met pl
dc.subject.en B-Raf pl
dc.subject.en mouse model pl
dc.description.volume 5 pl
dc.description.number 6 pl
dc.description.publication 0,6 pl
dc.identifier.doi 10.4172/2157-2518.1000200 pl
dc.title.journal Journal of Carcinogenesis & Mutagenesis pl
dc.language.container eng pl
dc.affiliation Wydział Biochemii, Biofizyki i Biotechnologii : Zakład Biofizyki pl
dc.subtype Article pl
dc.identifier.articleid 200 pl
dc.rights.original CC-BY; otwarte czasopismo; ostateczna wersja wydawcy; w momencie opublikowania; 0; pl
dc.identifier.project ROD UJ / P pl

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Udzielam licencji. Uznanie autorstwa Except where otherwise noted, this item's license is described as Udzielam licencji. Uznanie autorstwa