Repozytorium Uniwersytetu Jagiellońskiego

Circadian regulation of the Na^+/K^+-Atpase alpha subunit in the visual system is mediated by the pacemaker and by retina photoreceptors in Drosophila melanogaster

Circadian regulation of the Na^+/K^+-Atpase alpha ...

Metadane (Dublin Core)

dc.contributor.author Damulewicz, Milena [SAP13003948] pl
dc.contributor.author Rosato, Ezio pl
dc.contributor.author Pyza, Elżbieta [SAP11010854] pl
dc.date.accessioned 2015-07-02T11:30:00Z
dc.date.available 2015-07-02T11:30:00Z
dc.date.issued 2013 pl
dc.identifier.uri http://ruj.uj.edu.pl/xmlui/handle/item/11232
dc.language eng pl
dc.rights Dodaję tylko opis bibliograficzny *
dc.rights.uri *
dc.title Circadian regulation of the Na^+/K^+-Atpase alpha subunit in the visual system is mediated by the pacemaker and by retina photoreceptors in Drosophila melanogaster pl
dc.type JournalArticle pl
dc.abstract.en We investigated the diurnal oscillation in abundance of the catalytic α subunit of the sodium/potassium pump (ATPα) in the brain of Drosophila melanogaster. This rhythm is bimodal and is particularly robust in the glia cells of the lamina, the first optic neuropil. We observed loss of ATPα cycling in lamina glia in behaviourally arrhythmic per01 and tim01 mutants and in flies overexpressing the pro-apoptotic gene hid in the PDF-positive clock neurons. Moreover, the rhythm of ATPα abundance was altered in cry01 and Pdf0 mutants, in flies with a weakened clock mechanism in retina photoreceptor cells and in those subject to downregulation of the neuropeptide ITP by RNAi. This complex, rhythmic regulation of the α subunit suggests that the sodium/potassium pump may be a key target of the circadian pacemaker to impose daily control on brain activities, such as rhythmic changes in neuronal plasticity, which are best observed in the visual system. pl
dc.subject.en rhythmic size changes pl
dc.subject.en period clock gene pl
dc.subject.en Musca domestica pl
dc.description.volume 8 pl
dc.description.number 9 pl
dc.identifier.doi 10.1371/journal.pone.0073690 pl
dc.identifier.eissn 1932-6203 pl
dc.title.journal PLoS ONE pl
dc.language.container eng pl
dc.affiliation Wydział Biologii i Nauk o Ziemi : Instytut Zoologii pl
dc.subtype Article pl
dc.identifier.articleid e73690 pl
dc.rights.original CC-BY; otwarte czasopismo; ostateczna wersja wydawcy; w momencie opublikowania; 0; pl
.pointsMNiSW [2013 A]: 40


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