Repozytorium Uniwersytetu Jagiellońskiego

Application of capillary electrophoresis in determination of acid dissociation constant values

Application of capillary electrophoresis in determination ...

Metadane (Dublin Core) Nowak, Paweł [SAP14011291] pl Woźniakiewicz, Michał [SAP11019917] pl Kościelniak, Paweł [SAP11010982] pl 2015-07-02T07:49:24Z 2015-07-02T07:49:24Z 2015 pl
dc.identifier.issn 0021-9673 pl
dc.language eng pl
dc.title Application of capillary electrophoresis in determination of acid dissociation constant values pl
dc.type JournalArticle pl
dc.description.physical 1-12 pl
dc.abstract.en The chemical groups undergoing protonation or deprotonation in solution are described by the acid dissociation constant value, the key parameter for physicochemical characterization of biologically- and pharmacologically-important compounds. Capillary electrophoresis (CE) proved to be suitable technique for its determination: it enables automated and accurate measurements even for minute amount of sample, does not require the information about concentration, and handle both the impure and complex samples. In this review, a number of contributions reporting on the application of CE in pKa prediction has been summarized and critically discussed. The reader will find herein the brief introduction of theory, summary of all works published in the last decade, considerations on the most important innovations and achievements, and the discussion of pKa-related issues as e.g. the role of pKa-shifts in the chiral separation mechanism or the elucidation of migration order reversals observed during CE-mediated separations. pl
dc.subject.en acid dissociation constant pl
dc.subject.en Chiral separation pl
dc.subject.en Capillary electrophoresis pl
dc.subject.en Cosolvent systems pl
dc.subject.en Migration order reversal; pl
dc.subject.en pKa-shift pl
dc.description.volume 1377 pl
dc.identifier.doi 10.1016/j.chroma.2014.12.032 pl
dc.identifier.eissn 1873-3778 pl
dc.title.journal Journal of Chromatography. A pl
dc.language.container eng pl
dc.affiliation Wydział Chemii : Zakład Chemii Analitycznej pl
dc.subtype ReviewArticle pl
dc.rights.original bez licencji pl
dc.pbn.affiliation USOS78826:UJ.WCh; pl
.pointsMNiSW [2015 A]: 40

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