Repozytorium Uniwersytetu Jagiellońskiego

An intensified systemic trafficking of bone marrow-derived stem/progenitor cells in patients with pancreatic cancer

An intensified systemic trafficking of bone ...

Metadane (Dublin Core) Starzynska, Teresa pl Dabkowski, Krzysztof pl Blogowski, Wojciech pl Zuba-Surma, Ewa [SAP12019984] pl Budkowska, Marta pl Salata, Daria pl Dolegowska, Barbara pl Marlicz, Wojciech pl Lubikowski, Jerzy pl Ratajczak, Mariusz Z. pl 2015-06-26T07:14:31Z 2015-06-26T07:14:31Z 2013 pl
dc.identifier.issn 1582-1838 pl
dc.language eng pl
dc.rights Dodaję tylko opis bibliograficzny *
dc.rights.uri *
dc.title An intensified systemic trafficking of bone marrow-derived stem/progenitor cells in patients with pancreatic cancer pl
dc.type JournalArticle pl
dc.description.physical 792-799 pl
dc.description.additional Bibliogr. s. 798-799 pl
dc.abstract.en Various experimental studies indicate potential involvement of bone marrow (BM)-derived stem cells (SCs) in malignancy development and progression. In this study, we comprehensively analysed systemic trafficking of various populations of BM-derived SCs (BMSCs), i.e., mesenchymal, haematopoietic, endothelial stem/progenitor cells (MSCs, HSCs, EPCs respectively), and of recently discovered population of very small embryonic/epiblast-like SCs (VSELs) in pancreatic cancer patients. Circulating CD133^+/Lin^−/CD45^−/CD34^+ cells enriched for HSCs, CD105^+/STRO^-1^+/CD45− cells enriched for MSCs, CD34^+/KDR^+/CD31^+/CD45− cells enriched for EPCs and small CXCR4^+CD34^+CD133^+ subsets of Lin^−CD45^− cells that correspond to VSELs were enumerated and sorted from blood samples derived from 29 patients with pancreatic cancer, and 19 healthy controls. In addition, plasma levels of stromal-derived factor-1 (SDF-1), growth/inhibitory factors and sphingosine-1-phosphate (S1P; chemoattractants for SCs), as well as, of complement cascade (CC) molecules (C3a, C5a and C5b-9/membrane attack complex – MAC) were measured. Higher numbers of circulating VSELs and MSCs were detected in pancreatic cancer patients (P < 0.05 and 0.01 respectively). This trafficking of BMSCs was associated with significantly elevated C5a (P < 0.05) and C5b-9/MAC (P < 0.005) levels together with S1P concentrations detected in plasma of cancer patients, and seemed to be executed in a SDF-1 independent manner. In conclusion, we demonstrated that in patients with pancreatic cancer, intensified peripheral trafficking of selected populations of BMSCs occurs. This phenomenon seems to correlate with systemic activation of the CC, hepatocyte growth factor and S1P levels. In contrast to previous studies, we demonstrate herein that systemic SDF-1 levels do not seem to be linked with increased mobilization of stem cells in patients with pancreatic cancer. pl
dc.subject.en bone marrow-derived stem cells pl
dc.subject.en S1P pl
dc.subject.en SDF-1 pl
dc.subject.en pancreatic cancer pl
dc.subject.en inhibitory factors pl
dc.subject.en growth pl
dc.subject.en complement cascade pl
dc.description.volume 17 pl
dc.description.number 6 pl
dc.identifier.doi 10.1111/jcmm.12065 pl
dc.identifier.eissn 1582-4934 pl
dc.title.journal Journal of Cellular and Molecular Medicine pl
dc.language.container eng pl
dc.affiliation Wydział Biochemii, Biofizyki i Biotechnologii : Zakład Biologii Komórki pl
dc.subtype Article pl
dc.rights.original CC-BY; otwarte czasopismo; ostateczna wersja wydawcy; w momencie opublikowania; 0; pl
.pointsMNiSW [2013 A]: 35

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