Jagiellonian University Repository

Photoperiod-dependent effects of 4-tert-octylphenol on adherens and gap junction proteins in bank vole seminiferous tubules

pcg.skipToMenu

Photoperiod-dependent effects of 4-tert-octylphenol on adherens and gap junction proteins in bank vole seminiferous tubules

Show full item record

dc.contributor.author Hejmej, Anna [SAP11019511] pl
dc.contributor.author Kotula-Balak, Małgorzata [SAP11018137] pl
dc.contributor.author Chojnacka, Katarzyna [USOS65297] pl
dc.contributor.author Kuras, Paulina pl
dc.contributor.author Zarzycka, Marta [SAP20017863] pl
dc.contributor.author Bilińska, Barbara [SAP11008023] pl
dc.date.accessioned 2015-06-24T13:54:52Z
dc.date.available 2015-06-24T13:54:52Z
dc.date.issued 2013 pl
dc.identifier.issn 1687-8337 pl
dc.identifier.uri http://ruj.uj.edu.pl/xmlui/handle/item/10236
dc.language eng pl
dc.rights Udzielam licencji. Uznanie autorstwa 3.0 *
dc.rights.uri http://creativecommons.org/licenses/by/3.0/legalcode *
dc.title Photoperiod-dependent effects of 4-tert-octylphenol on adherens and gap junction proteins in bank vole seminiferous tubules pl
dc.type JournalArticle pl
dc.description.additional Marta Zarzycka podpisana jako Marta Łydka-Zarzycka pl
dc.abstract.en In the present study we evaluated in vivo and in vitro effects of 4-tert-octylphenol (OP) on the expression and distribution of adherens and gap junction proteins, N-cadherin, β-catenin, and connexin 43 (Cx43), in testes of seasonally breeding rodents, bank voles. We found that in bank vole testes expression and distribution of N-cadherin, β-catenin, and Cx43 were photoperiod dependent. Long-term treatment with OP (200 mg/kg b.w.) resulted in the reduction of junction proteins expressions ( , ) and their delocalization in the testes of males kept in long photoperiod, whereas in short-day animals slight increase of Cx43 ( ), N-cadherin, and β-catenin (statistically nonsignificant) levels was observed. Effects of OP appeared to be independent of FSH and were maintained during in vitro organ culture, indicating that OP acts directly on adherens and gap junction proteins in the testes. An experiment performed using an antiestrogen ICI 182,780 demonstrated that the biological effects of OP on β-catenin and Cx43 involve an estrogen receptor-mediated response. Taken together, in bank vole organization of adherens and gap junctions and their susceptibility to OP are related to the length of photoperiod. Alterations in cadherin/catenin and Cx43-based junction may partially result from activation of estrogen receptor α and/or β signaling pathway. pl
dc.subject.en bank vole pl
dc.subject.en connexin 43 pl
dc.subject.en testis pl
dc.subject.en 4-tert-octyphenol pl
dc.subject.en N-cadherin pl
dc.subject.en beta-catenin pl
dc.description.volume 2013 pl
dc.identifier.doi 10.1155/2013/134589 pl
dc.identifier.eissn 1687-8345 pl
dc.title.journal International Journal of Endocrinology pl
dc.language.container eng pl
dc.affiliation Wydział Biologii i Nauk o Ziemi : Instytut Zoologii pl
dc.subtype Article pl
dc.identifier.articleid 134589 pl
dc.rights.original CC-BY; otwarte czasopismo; ostateczna wersja wydawcy; w momencie opublikowania; 0; pl
dc.identifier.project ROD UJ / P pl
.pointsMNiSW [2013 A]: 20


Files in this item

This item appears in the following Collection(s)

Udzielam licencji. Uznanie autorstwa 3.0 Except where otherwise noted, this item's license is described as Udzielam licencji. Uznanie autorstwa 3.0