Photoperiod-dependent effects of 4-tert-octylphenol on adherens and gap junction proteins in bank vole seminiferous tubules

doi:10.1155/2013/134589

Photoperiod-dependent effects of 4-tert-octylphenol on adherens and gap junction proteins in bank vole seminiferous tubules

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Photoperiod-dependent effects of 4-tert-octylphenol on adherens and gap junction proteins in bank vole seminiferous tubules

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dc.contributor.author	Hejmej, Anna [SAP11019511]	pl
dc.contributor.author	Kotula-Balak, Małgorzata [SAP11018137]	pl
dc.contributor.author	Chojnacka, Katarzyna [USOS65297]	pl
dc.contributor.author	Kuras, Paulina	pl
dc.contributor.author	Zarzycka, Marta [SAP20017863]	pl
dc.contributor.author	Bilińska, Barbara [SAP11008023]	pl
dc.date.accessioned	2015-06-24T13:54:52Z
dc.date.available	2015-06-24T13:54:52Z
dc.date.issued	2013	pl
dc.identifier.issn	1687-8337	pl
dc.identifier.uri	http://ruj.uj.edu.pl/xmlui/handle/item/10236
dc.language	eng	pl
dc.rights	Udzielam licencji. Uznanie autorstwa 3.0	*
dc.rights.uri	http://creativecommons.org/licenses/by/3.0/legalcode	*
dc.title	Photoperiod-dependent effects of 4-tert-octylphenol on adherens and gap junction proteins in bank vole seminiferous tubules	pl
dc.type	JournalArticle	pl
dc.description.additional	Marta Zarzycka podpisana jako Marta Łydka-Zarzycka	pl
dc.abstract.en	In the present study we evaluated in vivo and in vitro effects of 4-tert-octylphenol (OP) on the expression and distribution of adherens and gap junction proteins, N-cadherin, β-catenin, and connexin 43 (Cx43), in testes of seasonally breeding rodents, bank voles. We found that in bank vole testes expression and distribution of N-cadherin, β-catenin, and Cx43 were photoperiod dependent. Long-term treatment with OP (200 mg/kg b.w.) resulted in the reduction of junction proteins expressions ( , ) and their delocalization in the testes of males kept in long photoperiod, whereas in short-day animals slight increase of Cx43 ( ), N-cadherin, and β-catenin (statistically nonsignificant) levels was observed. Effects of OP appeared to be independent of FSH and were maintained during in vitro organ culture, indicating that OP acts directly on adherens and gap junction proteins in the testes. An experiment performed using an antiestrogen ICI 182,780 demonstrated that the biological effects of OP on β-catenin and Cx43 involve an estrogen receptor-mediated response. Taken together, in bank vole organization of adherens and gap junctions and their susceptibility to OP are related to the length of photoperiod. Alterations in cadherin/catenin and Cx43-based junction may partially result from activation of estrogen receptor α and/or β signaling pathway.	pl
dc.subject.en	bank vole	pl
dc.subject.en	connexin 43	pl
dc.subject.en	testis	pl
dc.subject.en	4-tert-octyphenol	pl
dc.subject.en	N-cadherin	pl
dc.subject.en	beta-catenin	pl
dc.description.volume	2013	pl
dc.identifier.doi	10.1155/2013/134589	pl
dc.identifier.eissn	1687-8345	pl
dc.title.journal	International Journal of Endocrinology	pl
dc.language.container	eng	pl
dc.affiliation	Wydział Biologii i Nauk o Ziemi : Instytut Zoologii	pl
dc.subtype	Article	pl
dc.identifier.articleid	134589	pl
dc.rights.original	CC-BY; otwarte czasopismo; ostateczna wersja wydawcy; w momencie opublikowania; 0;	pl
dc.identifier.project	ROD UJ / P	pl
.pointsMNiSW	[2013 A]: 20