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Interactions of pentacyclic triterpene acids with cardiolipins and related phosphatidylglycerols in model systems

Interactions of pentacyclic triterpene acids with ...

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dc.contributor.author Broniatowski, Marcin [SAP11018406] pl
dc.contributor.author Flasiński, Michał [SAP13036957] pl
dc.contributor.author Zięba, Katarzyna [SAP13900783] pl
dc.contributor.author Miśkowiec, Paweł [SAP11019916] pl
dc.date.accessioned 2015-06-23T08:16:15Z
dc.date.available 2015-06-23T08:16:15Z
dc.date.issued 2014 pl
dc.identifier.issn 0005-2736 pl
dc.identifier.uri http://ruj.uj.edu.pl/xmlui/handle/item/10046
dc.language eng pl
dc.title Interactions of pentacyclic triterpene acids with cardiolipins and related phosphatidylglycerols in model systems pl
dc.type JournalArticle pl
dc.description.physical 2530-2538 pl
dc.abstract.en Pentacyclic triterpene acids (PTAs): betulinic (BAc), oleanolic (Ola) and ursolic (Urs) are potent pharmaceuticals applied in the therapy of cancer and bacterial infections. The mechanism of PTA action is multifactor, but the important step is their interaction with the lipids of mitochondrial and bacterial membranes. In our studies we applied the Langmuir monolayer technique to investigate the interactions between PTAs and cardiolipins (CLs) and phosphatidylglycerols (PGs). We applied two different mammalian mitochondrial CLs and one species extracted from the membrane of Escherichia coli. For comparison we performed the same experiments on the systems containing PTAs and 3 PGs strictly correlated structurally to the applied CLs. Our studies proved that PTAs can disturb the organization of CL-rich domains and affect the bacterial membrane fluidity by the interactions with phosphatidylglycerols, so anionic phospholipids are the targets of their membrane action. The thermodynamic interpretation of the results indicated that Urs has the highest membrane disorganizing potential among the 3 studied PTAs. The studies performed on model systems proved also that BAc can discriminate over structurally similar animal cardiolipin species, interacts specifically with BHCL — the main mammalian CL and can disturb its organization in the membrane. In contrast, Ola and Urs are much active as far as the interaction with bacterial CLs and PGs is concerned. pl
dc.description.volume 1838 pl
dc.description.number 10 pl
dc.identifier.doi 10.1016/j.bbamem.2014.05.027 pl
dc.identifier.eissn 1879-2642 pl
dc.title.journal Biochimica et Biophysica Acta. Biomembranes pl
dc.language.container eng pl
dc.affiliation Wydział Chemii : Zakład Chemii Środowiska pl
dc.subtype Article pl
dc.rights.original OTHER; otwarte czasopismo; ostateczna wersja wydawcy; po opublikowaniu; 12 pl
.pointsMNiSW [2014 A]: 35


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