Resonant activation is an effect of a noise-induced escape over a modulated potential barrier. The modulation of an energy landscape facilitates the escape kinetics and makes it optimal as measured by the mean first-passage time. A canonical example of resonant activation is a Brownian particle moving in a time-dependent potential under action of Gaussian white noise. Resonant activation is observed not only in typical Markovian-Gaussian systems but also in far-from-equilibrium and far-from-Markovianity regimes. We demonstrate that using an alternative to the mean first-passage time, robust measures of resonant activation, the signature of this effect can be observed in general continuous-time random walks in modulated potentials, even in situations when the mean first-passage time diverges.